ENSMUSG00000026812


Mus musculus

Features
Gene ID: ENSMUSG00000026812
  
Biological name :Tsc1
  
Synonyms : Hamartin / Q9EP53 / Tsc1
  
Possible biological names infered from orthology : Q92574 / TSC complex subunit 1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 28641228
Gene end: 28691167
  
Corresponding Affymetrix probe sets: 10470584 (MoGene1.0st)   1422043_at (Mouse Genome 430 2.0 Array)   1439989_at (Mouse Genome 430 2.0 Array)   1455252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120888
Ensembl peptide - ENSMUSP00000028155
Ensembl peptide - ENSMUSP00000109498
Ensembl peptide - ENSMUSP00000109500
Ensembl peptide - ENSMUSP00000109501
Ensembl peptide - ENSMUSP00000115380
NCBI entrez gene - 64930     See in Manteia.
MGI - MGI:1929183
RefSeq - XM_011239144
RefSeq - XM_006498220
RefSeq - XM_006498221
RefSeq - XM_006498222
RefSeq - XM_006498223
RefSeq - XM_011239142
RefSeq - XM_011239143
RefSeq - NM_001289575
RefSeq - NM_001289576
RefSeq - NM_022887
RefSeq Peptide - NP_075025
RefSeq Peptide - NP_001276504
RefSeq Peptide - NP_001276505
swissprot - F2Z3X2
swissprot - Q9EP53
swissprot - F2Z3W0
Ensembl - ENSMUSG00000026812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tsc1aENSDARG00000026048Danio rerio
 tsc1bENSDARG00000057918Danio rerio
 ENSGALG00000043548Gallus gallus
 ENSGALG00000003500Gallus gallus
 TSC1ENSG00000165699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007483  Hamartin
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001952 regulation of cell-matrix adhesion ISO
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0006407 rRNA export from nucleus ISO
 biological_processGO:0006417 regulation of translation ISO
 biological_processGO:0006813 potassium ion transport IMP
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008344 adult locomotory behavior ISS
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0016242 negative regulation of macroautophagy ISS
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021987 cerebral cortex development IMP
 biological_processGO:0030030 cell projection organization IMP
 biological_processGO:0032007 negative regulation of TOR signaling ISS
 biological_processGO:0032868 response to insulin ISO
 biological_processGO:0032956 regulation of actin cytoskeleton organization IBA
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0042552 myelination IMP
 biological_processGO:0043087 regulation of GTPase activity IBA
 biological_processGO:0043379 memory T cell differentiation IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0045792 negative regulation of cell size IMP
 biological_processGO:0045859 regulation of protein kinase activity IGI
 biological_processGO:0046323 glucose import IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051492 regulation of stress fiber assembly ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISO
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation ISS
 biological_processGO:1901214 regulation of neuron death ISS
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005938 cell cortex ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033596 TSC1-TSC2 complex IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051087 chaperone binding ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
Inhibition of TSC complex formation by PKB
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: KitlSl-t/Kitl+
Genetic Background: B6.Cg-KitlSl-t

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitlSl-t/Kitl+
Genetic Background: B6.Cg-KitlSl-t

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-t/Kitl+
Genetic Background: B6.Cg-KitlSl-t

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Pdpk1tm1Maka/Pdpk1tm1Maka,Tsc1tm1Djk/Tsc1tm1Djk,Tg(Gdf9-icre)5092Coo/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Stk11tm1Rdp/Stk11tm1Rdp
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda,Tsc1tm1.1Djk/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Artm1Verh/Y,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hoxa5tm1Rob/Hoxa5tm1Rob,Pdgfratm11(EGFP)Sor/Pdgfra+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * MF1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002035 leiomyosarcoma "malignant tumor derived from smooth (nonstriated) muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002045 renal cystadenoma "benign cystic neoplasm of the kidney derived from glandular epithelium origin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Myo7a816SB/Myo7a816SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * Balb/cOlaHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * C3H/HeNHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1.1Djk/Tsc1+
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002047 hepatic hemangioma "neoplastic- like masses in the liver; often undergoes spontaneous regression" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Myo7a816SB/Myo7a816SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * Balb/cOlaHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * C3H/HeNHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1.1Djk/Tsc1+
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002049 extremity angiosarcoma "malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Jrw/Gsk3b+,Irs2tm1Mfw/Irs2tm1Mfw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1.1Djk/Tsc1tm1.1Djk
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Nf1tm1Fcr/Nf1+,Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0002176 high brain weight "greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003462 abnormal response to novel odor "altered investigative behavior from controls in reactions associated with exposing an animal to a novel odor" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003570 uterine leiomyoma "a benign tumor derived from the smooth muscle tissue of the uterus" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
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Allelic Composition: Tsc1tm1.1Djk/Tsc1+
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myo7a816SB/Myo7a816SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * Balb/cOlaHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * C3H/HeNHsd * C57BL/6JOlaHsd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0004968 kidney epithelium hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Akt1tm1Hem/Akt1tm1Hem
Genetic Background: involves: 129P2/OlaHsd

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(tetO-Nras*Q61K)#Lc/0,Tg(Tyr-rtTA)37Lc/0
Genetic Background: FVB.Cg-Cdkn2atm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc

 MP:0005603 neuron hypertrophy "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008262 abnormal hippocampus region morphology "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Gt(ROSA)26Sortm1Sho/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1.1Djk,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(GFAP-cre)8Gtm/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0010309 increased mesothelioma incidence "greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0010384 increased renal carcinoma incidence "greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myo7a816SB/Myo7a816SB
Genetic Background: involves: BALB/cRl

Allelic Composition: Tsc1tm1Chdl/Tsc1+
Genetic Background: involves: 129P2/OlaHsd * Balb/cOlaHsd * C57BL/6JOlaHsd

Allelic Composition: Tsc1tm1.1Djk/Tsc1+
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J * C57BL/6NTac * CBA

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pax8-rtTA2S*M2)1Koes/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myo7a816SB/Myo7a816SB
Genetic Background: involves: BALB/cRl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Lin28atm1.1Gqda/Lin28atm1.1Gqda,Tsc1tm1.1Djk/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: NhsXcat/Nhs+
Genetic Background: involves: DBA/2 * T STOCK

Allelic Composition: Tsc1tm1.1Djk/Tsc1tm1.1Djk
Genetic Background: either: 129S4/SvJae-Tsc1tm1Djk or (involves: 129S4/SvJae * BALB/cJ) or (involves: 129S4/SvJae * C57BL/6J)

Allelic Composition: Tsc1tm1Hin/Tsc1tm1Hin
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tsc1tm1Chdl/Tsc1tm1Chdl
Genetic Background: B6NHsd.129P2-Tsc1tm1Chdl

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0013140 excessive vocalization "producing sound from the vocal organs more frequently or more loudly than expected" [MGI:Ahmad_Retha]
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Allelic Composition: Tsc1tm1Djk/Tsc1+,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cJ * C57BL/6J

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
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Allelic Composition: Trp53tm1Brn/Trp53tm1Brn,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Rhebtm1.1Yelg/Rhebtm1.1Yelg
Genetic Background: B6.129P2-Rhebtm1.1Yelg

Allelic Composition: Tsc1tm1Chdl/Tsc1tm1Chdl
Genetic Background: B6NHsd.129P2-Tsc1tm1Chdl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021368 Q9D0K0 / Tbc1d7 / TBC1 domain family member 7 / Q9P0N9*  / complex / reaction
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / complex / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000004056 Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction






 

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