ENSMUSG00000028944


Mus musculus

Features
Gene ID: ENSMUSG00000028944
  
Biological name :Prkag2
  
Synonyms : Prkag2 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q91WG5
  
Possible biological names infered from orthology : protein kinase AMP-activated non-catalytic subunit gamma 2 / Q9UGJ0
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 24862744
Gene end: 25100642
  
Corresponding Affymetrix probe sets: 10528702 (MoGene1.0st)   1423831_at (Mouse Genome 430 2.0 Array)   1423832_at (Mouse Genome 430 2.0 Array)   1431263_at (Mouse Genome 430 2.0 Array)   1451140_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114978
Ensembl peptide - ENSMUSP00000110626
Ensembl peptide - ENSMUSP00000115760
Ensembl peptide - ENSMUSP00000117149
Ensembl peptide - ENSMUSP00000030784
Ensembl peptide - ENSMUSP00000075651
NCBI entrez gene - 108099     See in Manteia.
MGI - MGI:1336153
RefSeq - XM_017320596
RefSeq - NM_001170555
RefSeq - NM_001170556
RefSeq - NM_001310480
RefSeq - NM_145401
RefSeq - XM_006535611
RefSeq - XM_006535612
RefSeq - XM_006535614
RefSeq - XM_011249740
RefSeq - XM_017320595
RefSeq Peptide - NP_663376
RefSeq Peptide - NP_001164026
RefSeq Peptide - NP_001164027
RefSeq Peptide - NP_001297409
swissprot - Q8BIQ9
swissprot - Q91WG5
swissprot - D3YUS1
swissprot - D3Z5V5
swissprot - D3YYW4
swissprot - Q3TMN8
Ensembl - ENSMUSG00000028944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkag2aENSDARG00000012625Danio rerio
 prkag2bENSDARG00000001933Danio rerio
 PRKAG2ENSGALG00000006219Gallus gallus
 PRKAG2ENSG00000106617Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*ENSMUSG0000006771342
Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*ENSMUSG0000000654238


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process ISO
 biological_processGO:0006110 regulation of glycolytic process ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation ISO
 biological_processGO:0019217 regulation of fatty acid metabolic process ISO
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0045860 positive regulation of protein kinase activity ISO
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004679 AMP-activated protein kinase activity TAS
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity ISO
 molecular_functionGO:0008607 phosphorylase kinase regulator activity ISO
 molecular_functionGO:0016208 AMP binding IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030295 protein kinase activator activity ISO
 molecular_functionGO:0043531 ADP binding ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0004115 abnormal sinoatrial node morphology "structural anomaly in the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atruim that is the source of contraction impulses for the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

Allelic Composition: Prkag2tm1.1Geno/Prkag2tm1.1Geno,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
Show

Allelic Composition: Anp32btm1Mak/Anp32btm1Mak
Genetic Background: FVB.129P2(B6)-Anp32btm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003068 Stk11 / Q9WTK7 / Serine/threonine-protein kinase STK11 / Q15831* / serine/threonine kinase 11*  / reaction
 ENSMUSG00000021096 Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*  / reaction
 ENSMUSG00000025907 Q9ESK9 / Rb1cc1 / RB1-inducible coiled-coil protein 1 / Q8TDY2* / RB1 inducible coiled-coil 1*  / complex / reaction
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / complex
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction
 ENSMUSG00000035086 Becn1 / O88597 / Beclin-1 Beclin-1-C 35 kDa Beclin-1-C 37 kDa / Q14457* / beclin 1*  / reaction
 ENSMUSG00000037204 Atg101 / Q9D8Z6 / Autophagy-related protein 101 / Q9BSB4* / autophagy related 101*  / reaction / complex
 ENSMUSG00000028893 Sesn2 / P58043 / Sestrin-2 / P58004*  / complex / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / reaction
 ENSMUSG00000002496 Tsc2 / tuberous sclerosis 2 / P49815* / TSC complex subunit 2*  / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / reaction
 ENSMUSG00000027244 Atg13 / Q91YI1 / Mus musculus autophagy related 13 (Atg13), transcript variant 4, mRNA. / O75143* / autophagy related 13*  / reaction / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / reaction
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction
 ENSMUSG00000064063 BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / complex
 ENSMUSG00000040506 A2AH22 / Ambra1 / Activating molecule in BECN1-regulated autophagy protein 1 / Q9C0C7* / autophagy and beclin 1 regulator 1*  / reaction
 ENSMUSG00000026812 Tsc1 / Q9EP53 / Hamartin / Q92574* / TSC complex subunit 1*  / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction
 ENSMUSG00000029512 Ulk1 / unc-51 like kinase 1 / O75385* / unc-51 like autophagy activating kinase 1*  / complex / reaction
 ENSMUSG00000038332 Sesn1 / P58006 / Sestrin-1 / Q9Y6P5*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / reaction
 ENSMUSG00000020483 Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*  / reaction
 ENSMUSG00000029167 O70343 / Ppargc1a / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha / Q9UBK2* / PPARG coactivator 1 alpha*  / reaction
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / reaction
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / reaction
 ENSMUSG00000037526 Atg14 / Q8CDJ3 / Beclin 1-associated autophagy-related key regulator / Q6ZNE5* / autophagy related 14*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / complex
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr