ENSMUSG00000021096


Mus musculus

Features
Gene ID: ENSMUSG00000021096
  
Biological name :Ppm1a
  
Synonyms : P49443 / Ppm1a / protein phosphatase 1A, magnesium dependent, alpha isoform
  
Possible biological names infered from orthology : P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 72757455
Gene end: 72799819
  
Corresponding Affymetrix probe sets: 10396358 (MoGene1.0st)   10339030 (MoGene1.0st)   10339685 (MoGene1.0st)   10340686 (MoGene1.0st)   10340757 (MoGene1.0st)   10341095 (MoGene1.0st)   10341606 (MoGene1.0st)   10341714 (MoGene1.0st)   10341769 (MoGene1.0st)   10342324 (MoGene1.0st)   10342532 (MoGene1.0st)   10343252 (MoGene1.0st)   10344023 (MoGene1.0st)   10339066 (MoGene1.0st)   10339186 (MoGene1.0st)   10339244 (MoGene1.0st)   10339339 (MoGene1.0st)   10340176 (MoGene1.0st)   10340986 (MoGene1.0st)   10341442 (MoGene1.0st)   10341482 (MoGene1.0st)   10342117 (MoGene1.0st)   10342335 (MoGene1.0st)   10342547 (MoGene1.0st)   10342651 (MoGene1.0st)   10343005 (MoGene1.0st)   10343972 (MoGene1.0st)   10344456 (MoGene1.0st)   10344478 (MoGene1.0st)   1415678_at (Mouse Genome 430 2.0 Array)   1417221_at (Mouse Genome 430 2.0 Array)   1425537_at (Mouse Genome 430 2.0 Array)   1428978_at (Mouse Genome 430 2.0 Array)   1429500_at (Mouse Genome 430 2.0 Array)   1429501_s_at (Mouse Genome 430 2.0 Array)   1443903_at (Mouse Genome 430 2.0 Array)   1451943_a_at (Mouse Genome 430 2.0 Array)   1452989_at (Mouse Genome 430 2.0 Array)   1453171_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152116
Ensembl peptide - ENSMUSP00000152650
Ensembl peptide - ENSMUSP00000152472
Ensembl peptide - ENSMUSP00000152372
Ensembl peptide - ENSMUSP00000021514
NCBI entrez gene - 19042     See in Manteia.
MGI - MGI:99878
RefSeq - XM_006515603
RefSeq - NM_008910
RefSeq Peptide - NP_032936
swissprot - A0A1Y7VL98
swissprot - A0A1Y7VNK7
swissprot - P49443
swissprot - Q9EQE2
swissprot - A0A1Y7VJZ4
Ensembl - ENSMUSG00000021096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1aaENSDARG00000032155Danio rerio
 ppm1abENSDARG00000043250Danio rerio
 PPM1AENSGALG00000011917Gallus gallus
 PPM1AENSG00000100614Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppm1b / P36993 / protein phosphatase 1B, magnesium dependent, beta isoform / O75688* / protein phosphatase, Mg2+/Mn2+ dependent 1B*ENSMUSG0000006113075
Ppm1n / Q8BGL1 / Probable protein phosphatase 1N / Q8N819* / protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)*ENSMUSG0000003040243


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR012911  Protein serine/threonine phosphatase 2C, C-terminal
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily
 IPR036580  Phosphatase 2C, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006499 N-terminal protein myristoylation IDA
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046827 positive regulation of protein export from nucleus IMP
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Energy dependent regulation of mTOR by LKB1-AMPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
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Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1(Irx3*)Hui/Gt(ROSA)26Sor+,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
Show

Allelic Composition: HadhGt(RRM279)Byg/HadhGt(RRM279)Byg
Genetic Background: B6.129P2-HadhGt(RRM279)Byg

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029513 Prkab1 / Q9R078 / protein kinase, AMP-activated, beta 1 non-catalytic subunit / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1*  / reaction
 ENSMUSG00000038205 Prkab2 / Q6PAM0 / protein kinase, AMP-activated, beta 2 non-catalytic subunit / O43741* / protein kinase AMP-activated non-catalytic subunit beta 2*  / reaction
 ENSMUSG00000028518 Prkaa2 / Q8BRK8 / protein kinase, AMP-activated, alpha 2 catalytic subunit / P54646* / protein kinase AMP-activated catalytic subunit alpha 2*  / reaction
 ENSMUSG00000006542 Prkag3 / Q8BGM7 / protein kinase, AMP-activated, gamma 3 non-catatlytic subunit / Q9UGI9* / protein kinase AMP-activated non-catalytic subunit gamma 3*  / reaction
 ENSMUSG00000028944 Prkag2 / Q91WG5 / protein kinase, AMP-activated, gamma 2 non-catalytic subunit / Q9UGJ0* / protein kinase AMP-activated non-catalytic subunit gamma 2*  / reaction
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / complex / reaction
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / reaction / complex
 ENSMUSG00000067713 O54950 / Prkag1 / protein kinase, AMP-activated, gamma 1 non-catalytic subunit / P54619* / protein kinase AMP-activated non-catalytic subunit gamma 1*  / reaction
 ENSMUSG00000050697 Prkaa1 / Q5EG47 / protein kinase, AMP-activated, alpha 1 catalytic subunit / Q13131* / protein kinase AMP-activated catalytic subunit alpha 1*  / reaction
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / complex / reaction






 

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