ENSMUSG00000061130


Mus musculus

Features
Gene ID: ENSMUSG00000061130
  
Biological name :Ppm1b
  
Synonyms : P36993 / Ppm1b / protein phosphatase 1B, magnesium dependent, beta isoform
  
Possible biological names infered from orthology : O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1B
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: E4
Gene start: 84956741
Gene end: 85023991
  
Corresponding Affymetrix probe sets: 10447254 (MoGene1.0st)   1425330_a_at (Mouse Genome 430 2.0 Array)   1426382_at (Mouse Genome 430 2.0 Array)   1451669_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079107
Ensembl peptide - ENSMUSP00000107923
Ensembl peptide - ENSMUSP00000107924
Ensembl peptide - ENSMUSP00000107926
NCBI entrez gene - 19043     See in Manteia.
MGI - MGI:101841
RefSeq - XM_011246323
RefSeq - NM_001159496
RefSeq - NM_001159497
RefSeq - NM_001159498
RefSeq - NM_011151
RefSeq - XM_006523860
RefSeq - XM_006523861
RefSeq - XM_006523862
RefSeq - XM_011246321
RefSeq - XM_011246322
RefSeq Peptide - NP_001152970
RefSeq Peptide - NP_001152968
RefSeq Peptide - NP_001152969
RefSeq Peptide - NP_035281
swissprot - Q546R1
swissprot - P36993
swissprot - Q99NF7
Ensembl - ENSMUSG00000061130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1baENSDARG00000001888Danio rerio
 ppm1bbENSDARG00000011496Danio rerio
 PPM1BENSGALG00000030691Gallus gallus
 PPM1BENSG00000138032Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ppm1a / P49443 / protein phosphatase 1A, magnesium dependent, alpha isoform / P35813* / protein phosphatase, Mg2+/Mn2+ dependent 1A*ENSMUSG0000002109660
Ppm1n / Q8BGL1 / Probable protein phosphatase 1N / Q8N819* / protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)*ENSMUSG0000003040235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR012911  Protein serine/threonine phosphatase 2C, C-terminal
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily
 IPR036580  Phosphatase 2C, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IMP
 biological_processGO:0006499 N-terminal protein myristoylation IDA
 biological_processGO:0032688 negative regulation of interferon-beta production ISS
 biological_processGO:0035970 peptidyl-threonine dephosphorylation ISO
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0050687 negative regulation of defense response to virus ISS
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grid1tm1Jnz/Grid1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Grid1tm1Jnz/Grid1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025234 Arih1 / Q9Z1K5 / E3 ubiquitin-protein ligase ARIH1 / Q9Y4X5* / ariadne RBR E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000035692 Isg15 / Q64339 / Ubiquitin-like protein ISG15 / P05161* / ISG15 ubiquitin-like modifier*  / complex / reaction
 ENSMUSG00000027078 Q9QZU9 / Ube2l6 / ubiquitin-conjugating enzyme E2L 6 / O14933*  / reaction






 

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