ENSG00000100614


Homo sapiens

Features
Gene ID: ENSG00000100614
  
Biological name :PPM1A
  
Synonyms : P35813 / PPM1A / protein phosphatase, Mg2+/Mn2+ dependent 1A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.1
Gene start: 60245752
Gene end: 60299087
  
Corresponding Affymetrix probe sets: 203966_s_at (Human Genome U133 Plus 2.0 Array)   210407_at (Human Genome U133 Plus 2.0 Array)   227728_at (Human Genome U133 Plus 2.0 Array)   229027_at (Human Genome U133 Plus 2.0 Array)   231370_at (Human Genome U133 Plus 2.0 Array)   235344_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000327255
Ensembl peptide - ENSP00000314850
Ensembl peptide - ENSP00000378514
Ensembl peptide - ENSP00000437200
Ensembl peptide - ENSP00000436445
Ensembl peptide - ENSP00000435575
Ensembl peptide - ENSP00000435398
Ensembl peptide - ENSP00000431453
NCBI entrez gene - 5494     See in Manteia.
OMIM - 606108
RefSeq - XM_017021387
RefSeq - XM_011536881
RefSeq - XM_011536882
RefSeq - XM_011536883
RefSeq - XM_011536884
RefSeq - XM_017021381
RefSeq - XM_017021382
RefSeq - XM_017021383
RefSeq - XM_017021384
RefSeq - XM_017021385
RefSeq - XM_017021386
RefSeq - NM_021003
RefSeq - NM_177951
RefSeq - NM_177952
RefSeq - XM_005267779
RefSeq - XM_005267781
RefSeq - XM_011536872
RefSeq - XM_011536876
RefSeq - XM_011536877
RefSeq - XM_011536878
RefSeq - XM_011536879
RefSeq - XM_011536880
RefSeq Peptide - NP_808820
RefSeq Peptide - NP_808821
RefSeq Peptide - NP_066283
swissprot - E9PKB5
swissprot - E9PJN3
swissprot - E9PP44
swissprot - P35813
swissprot - A0A024R6A5
swissprot - E9PNE1
swissprot - E9PL75
Ensembl - ENSG00000100614
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppm1aaENSDARG00000032155Danio rerio
 ppm1abENSDARG00000043250Danio rerio
 PPM1AENSGALG00000011917Gallus gallus
 Ppm1aENSMUSG00000021096Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPM1B / O75688 / protein phosphatase, Mg2+/Mn2+ dependent 1BENSG0000013803264
PPM1N / Q8N819 / protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)ENSG0000021388936


Protein motifs (from Interpro)
Interpro ID Name
 IPR000222  PPM-type phosphatase, divalent cation binding
 IPR001932  PPM-type phosphatase domain
 IPR012911  Protein serine/threonine phosphatase 2C, C-terminal
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily
 IPR036580  Phosphatase 2C, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006499 N-terminal protein myristoylation ISS
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly IDA
 biological_processGO:0016055 Wnt signaling pathway IDA
 biological_processGO:0016311 dephosphorylation IDA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IDA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0035970 peptidyl-threonine dephosphorylation IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046827 positive regulation of protein export from nucleus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0033192 calmodulin-dependent protein phosphatase activity IDA
 molecular_functionGO:0043169 cation binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Energy dependent regulation of mTOR by LKB1-AMPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / complex / reaction
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / reaction / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction






 

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