Manteia

ENSG00000115592

Homo sapiens

Features

Gene ID:	ENSG00000115592

Biological name :	PRKAG3

Synonyms :	PRKAG3 / protein kinase AMP-activated non-catalytic subunit gamma 3 / Q9UGI9

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	2
Strand:	-1
Band:	q35
Gene start:	218822383
Gene end:	218832086

Corresponding Affymetrix probe sets:	223904_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000233944 Ensembl peptide - ENSP00000436068 Ensembl peptide - ENSP00000419272 Ensembl peptide - ENSP00000416100 Ensembl peptide - ENSP00000397133 NCBI entrez gene - 53632 See in Manteia. OMIM - 604976 RefSeq - XM_017004343 RefSeq - NM_017431 RefSeq Peptide - NP_059127 swissprot - B4DUK8 swissprot - C9JIC7 swissprot - Q9UGI9 swissprot - A0A024R426 Ensembl - ENSG00000115592

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
prkag3a	ENSDARG00000017537	Danio rerio
prkag3b	ENSDARG00000000369	Danio rerio
PRKAG3	ENSGALG00000011360	Gallus gallus
Prkag3	ENSMUSG00000006542	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2	ENSG00000106617	45
P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1	ENSG00000181929	40

Protein motifs (from Interpro)

Interpro ID	Name
IPR000644	CBS domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0005978	glycogen biosynthetic process	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	IEA
biological_process	GO:0006633	fatty acid biosynthetic process	IEA
biological_process	GO:0007050	cell cycle arrest	TAS
biological_process	GO:0016236	macroautophagy	TAS
biological_process	GO:0016241	regulation of macroautophagy	TAS
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0035556	intracellular signal transduction	TAS
biological_process	GO:1901796	regulation of signal transduction by p53 class mediator	TAS
cellular_component	GO:0005615	extracellular space	HDA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0031588	nucleotide-activated protein kinase complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004679	AMP-activated protein kinase activity	TAS
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0019901	protein kinase binding	IDA

Pathways (from Reactome)

Pathway description

Translocation of SLC2A4 (GLUT4) to the plasma membrane

Macroautophagy

Activation of PPARGC1A (PGC-1alpha) by phosphorylation

Energy dependent regulation of mTOR by LKB1-AMPK

TP53 Regulates Metabolic Genes

Regulation of TP53 Activity through Phosphorylation

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000023287	Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1	/ complex / reaction
ENSG00000111725	PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1	/ complex
ENSG00000131791	O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2	/ complex
ENSG00000167965	MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog	/ reaction
ENSG00000080546	SESN1 / Q9Y6P5 / sestrin 1	/ reaction / complex
ENSG00000141564	RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1	/ reaction
ENSG00000083750	RRAGB / Q5VZM2 / Ras related GTP binding B	/ reaction
ENSG00000132356	PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1	/ complex
ENSG00000126775	ATG14 / Q6ZNE5 / autophagy related 14	/ reaction
ENSG00000264364	DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2	/ reaction
ENSG00000123395	ATG101 / Q9BSB4 / autophagy related 101	/ reaction / complex
ENSG00000025039	RRAGD / Q9NQL2 / Ras related GTP binding D	/ reaction
ENSG00000198793	MTOR / P42345 / mechanistic target of rapamycin kinase	/ reaction
ENSG00000141510	TP53 / P04637 / tumor protein p53	/ reaction
ENSG00000196455	PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4	/ reaction
ENSG00000106615	RHEB / Q15382 / Ras homolog, mTORC1 binding	/ reaction
ENSG00000165699	TSC1 / Q92574 / TSC complex subunit 1	/ reaction
ENSG00000130766	SESN2 / P58004 / sestrin 2	/ reaction / complex
ENSG00000110497	AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1	/ reaction
ENSG00000177058	Q8NBW4 / SLC38A9 / solute carrier family 38 member 9	/ reaction
ENSG00000162409	P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2	/ complex
ENSG00000103197	TSC2 / P49815 / TSC complex subunit 2	/ reaction
ENSG00000088986	DYNLL1 / P63167 / dynein light chain LC8-type 1	/ reaction
ENSG00000078142	PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3	/ reaction
ENSG00000177169	ULK1 / O75385 / unc-51 like autophagy activating kinase 1	/ reaction / complex
ENSG00000126581	BECN1 / Q14457 / beclin 1	/ reaction
ENSG00000155876	RRAGA / Q7L523 / Ras related GTP binding A	/ reaction
ENSG00000175224	ATG13 / O75143 / autophagy related 13	/ reaction / complex
ENSG00000116954	RRAGC / Q9HB90 / Ras related GTP binding C	/ reaction
ENSG00000109819	Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha	/ reaction
ENSG00000100614	PPM1A / P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A	/ reaction
ENSG00000118046	STK11 / Q15831 / serine/threonine kinase 11	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr