ENSG00000130766


Homo sapiens

Features
Gene ID: ENSG00000130766
  
Biological name :SESN2
  
Synonyms : P58004 / SESN2 / sestrin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p35.3
Gene start: 28259527
Gene end: 28282491
  
Corresponding Affymetrix probe sets: 223195_s_at (Human Genome U133 Plus 2.0 Array)   223196_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000253063
NCBI entrez gene - 83667     See in Manteia.
OMIM - 607767
RefSeq - NM_031459
RefSeq Peptide - NP_113647
swissprot - P58004
Ensembl - ENSG00000130766
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sesn2ENSDARG00000070012Danio rerio
 SESN2ENSGALG00000037603Gallus gallus
 Sesn2ENSMUSG00000028893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SESN1 / Q9Y6P5 / sestrin 1ENSG0000008054656
SESN3 / P58005 / sestrin 3ENSG0000014921255


Protein motifs (from Interpro)
Interpro ID Name
 IPR006730  Sestrin
 IPR029032  AhpD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006635 fatty acid beta-oxidation IEA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016239 positive regulation of macroautophagy IMP
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0032042 mitochondrial DNA metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0046323 glucose import IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070328 triglyceride homeostasis IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071233 cellular response to leucine IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IMP
 biological_processGO:0098869 cellular oxidant detoxification IMP
 biological_processGO:1900182 positive regulation of protein localization to nucleus IMP
 biological_processGO:1901031 regulation of response to reactive oxygen species IEA
 biological_processGO:1902010 negative regulation of translation in response to endoplasmic reticulum stress IMP
 biological_processGO:1904262 negative regulation of TORC1 signaling IEA
 biological_processGO:1904504 positive regulation of lipophagy IEA
 biological_processGO:1990253 cellular response to leucine starvation IMP
 biological_processGO:2000479 regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 cellular_componentGO:0031932 TORC2 complex IEA
 cellular_componentGO:0061700 GATOR2 complex IDA
 cellular_componentGO:1990316 Atg1/ULK1 kinase complex IDA
 molecular_functionGO:0005092 GDP-dissociation inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016684 oxidoreductase activity, acting on peroxide as acceptor IDA
 molecular_functionGO:0032542 sulfiredoxin activity IDA
 molecular_functionGO:0070728 leucine binding IDA


Pathways (from Reactome)
Pathway description
TP53 Regulates Metabolic Genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / complex / reaction
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction / complex
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction / complex
 ENSG00000117450 PRDX1 / Q06830 / peroxiredoxin 1  / reaction / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction / complex
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / complex / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex / reaction






 

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