ENSG00000111725


Homo sapiens

Features
Gene ID: ENSG00000111725
  
Biological name :PRKAB1
  
Synonyms : PRKAB1 / protein kinase AMP-activated non-catalytic subunit beta 1 / Q9Y478
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.23
Gene start: 119667753
Gene end: 119681630
  
Corresponding Affymetrix probe sets: 201834_at (Human Genome U133 Plus 2.0 Array)   201835_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441369
Ensembl peptide - ENSP00000486936
Ensembl peptide - ENSP00000444816
Ensembl peptide - ENSP00000229328
Ensembl peptide - ENSP00000437993
Ensembl peptide - ENSP00000439235
NCBI entrez gene - 5564     See in Manteia.
OMIM - 602740
RefSeq - NM_006253
RefSeq - XM_005253909
RefSeq Peptide - NP_006244
swissprot - Q9Y478
swissprot - F5H610
swissprot - F5H2X8
swissprot - F5H4Y8
swissprot - A0A024RBN1
Ensembl - ENSG00000111725
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkab1aENSDARG00000044183Danio rerio
 prkab1bENSDARG00000046143Danio rerio
 PRKAB1ENSGALG00000007373Gallus gallus
 Prkab1ENSMUSG00000029513Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2ENSG0000013179171


Protein motifs (from Interpro)
Interpro ID Name
 IPR006828  Association with the SNF1 complex (ASC) domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032640  AMP-activated protein kinase, glycogen-binding domain
 IPR037256  ASC domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035878 nail development IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction / complex
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / reaction
 ENSG00000080546 SESN1 / Q9Y6P5 / sestrin 1  / reaction / complex
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / complex
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000165699 TSC1 / Q92574 / TSC complex subunit 1  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / complex
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction
 ENSG00000130766 SESN2 / P58004 / sestrin 2  / reaction / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex
 ENSG00000103197 TSC2 / P49815 / TSC complex subunit 2  / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / complex
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction / complex
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / complex
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction / complex
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / reaction
 ENSG00000100614 PPM1A / P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A  / reaction
 ENSG00000118046 STK11 / Q15831 / serine/threonine kinase 11  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr