ENSG00000126775


Homo sapiens

Features
Gene ID: ENSG00000126775
  
Biological name :ATG14
  
Synonyms : ATG14 / autophagy related 14 / Q6ZNE5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q22.3
Gene start: 55366392
Gene end: 55411858
  
Corresponding Affymetrix probe sets: 204568_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000247178
NCBI entrez gene - 22863     See in Manteia.
OMIM - 613515
RefSeq - NM_014924
RefSeq - XM_011536563
RefSeq Peptide - NP_055739
swissprot - Q6ZNE5
Ensembl - ENSG00000126775
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATG14ENSDARG00000002670Danio rerio
 ATG14ENSGALG00000012148Gallus gallus
 Atg14ENSMUSG00000037526Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018791  UV radiation resistance protein/autophagy-related protein 14


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000423 mitophagy IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0001933 negative regulation of protein phosphorylation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008333 endosome to lysosome transport IGI
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016240 autophagosome membrane docking IDA
 biological_processGO:0042149 cellular response to glucose starvation ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0061635 regulation of protein complex stability IC
 biological_processGO:0098780 response to mitochondrial depolarisation IMP
 cellular_componentGO:0000421 autophagosome membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034045 phagophore assembly site membrane TAS
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III ISS
 cellular_componentGO:0097629 extrinsic component of omegasome membrane IDA
 cellular_componentGO:0097632 extrinsic component of phagophore assembly site membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / complex / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / complex
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / complex
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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