ENSG00000196455


Homo sapiens

Features
Gene ID: ENSG00000196455
  
Biological name :PIK3R4
  
Synonyms : phosphoinositide-3-kinase regulatory subunit 4 / PIK3R4 / Q99570
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q22.1
Gene start: 130678935
Gene end: 130746829
  
Corresponding Affymetrix probe sets: 212740_at (Human Genome U133 Plus 2.0 Array)   216436_at (Human Genome U133 Plus 2.0 Array)   216752_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349205
Ensembl peptide - ENSP00000427302
Ensembl peptide - ENSP00000424274
Ensembl peptide - ENSP00000422767
NCBI entrez gene - 30849     See in Manteia.
OMIM - 602610
RefSeq - NM_014602
RefSeq Peptide - NP_055417
swissprot - D6RBB7
swissprot - D6RAC3
swissprot - D6RJ98
swissprot - Q99570
Ensembl - ENSG00000196455
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r4ENSDARG00000060469Danio rerio
 PIK3R4ENSGALG00000040917Gallus gallus
 Pik3r4ENSMUSG00000032571Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001680  WD40 repeat
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR021133  HEAT, type 2
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0006623 protein targeting to vacuole IBA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030242 autophagy of peroxisome IBA
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0032801 receptor catabolic process IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0045324 late endosome to vacuole transport IBA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0071561 nucleus-vacuole junction IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity NAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Macroautophagy
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Toll Like Receptor 9 (TLR9) Cascade
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / complex
 ENSG00000198382 UVRAG / Q9P2Y5 / UV radiation resistance associated  / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / complex / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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