ENSG00000162409


Homo sapiens

Features
Gene ID: ENSG00000162409
  
Biological name :PRKAA2
  
Synonyms : P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p32.2
Gene start: 56645322
Gene end: 56715335
  
Corresponding Affymetrix probe sets: 207709_at (Human Genome U133 Plus 2.0 Array)   227892_at (Human Genome U133 Plus 2.0 Array)   238441_at (Human Genome U133 Plus 2.0 Array)   238489_at (Human Genome U133 Plus 2.0 Array)   240349_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481378
Ensembl peptide - ENSP00000360290
NCBI entrez gene - 5563     See in Manteia.
OMIM - 600497
RefSeq - XM_017001694
RefSeq - NM_006252
RefSeq - XM_017001692
RefSeq - XM_017001693
RefSeq Peptide - NP_006243
swissprot - A0A087WXX9
swissprot - P54646
Ensembl - ENSG00000162409
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkaa2ENSDARG00000060641Danio rerio
 PRKAA2ENSGALG00000010826Gallus gallus
 Prkaa2ENSMUSG00000028518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1ENSG0000013235677
NUAK2 / Q9H093 / NUAK family kinase 2ENSG0000016354531
NUAK1 / O60285 / NUAK family kinase 1ENSG0000007459031
TRIB1 / Q96RU8 / tribbles pseudokinase 1ENSG0000017333414
TRIB2 / Q92519 / tribbles pseudokinase 2ENSG0000007157514
TRIB3 / Q96RU7 / tribbles pseudokinase 3ENSG0000010125514
STK40 / Q8N2I9 / serine/threonine kinase 40ENSG0000019618213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR032270  AMPK, C-terminal adenylate sensor domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006853 carnitine shuttle TAS
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0014850 response to muscle activity IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016239 positive regulation of macroautophagy TAS
 biological_processGO:0016241 regulation of macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0035404 histone-serine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042304 regulation of fatty acid biosynthetic process TAS
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045821 positive regulation of glycolytic process ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0055089 fatty acid homeostasis ISS
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004679 AMP-activated protein kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035174 histone serine kinase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
 molecular_functionGO:0050405 [acetyl-CoA carboxylase] kinase activity IEA


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Import of palmitoyl-CoA into the mitochondrial matrix
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / complex
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / complex
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / complex
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000100614 PPM1A / P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A  / reaction
 ENSG00000118046 STK11 / Q15831 / serine/threonine kinase 11  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction
 ENSG00000065882 Q86TI0 / TBC1D1 / TBC1 domain family member 1  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction
 ENSG00000130766 SESN2 / P58004 / sestrin 2  / reaction / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction
 ENSG00000009950 MLXIPL / Q9NP71 / MLX interacting protein like  / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction
 ENSG00000103197 TSC2 / P49815 / TSC complex subunit 2  / reaction
 ENSG00000165699 TSC1 / Q92574 / TSC complex subunit 1  / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / reaction
 ENSG00000080546 SESN1 / Q9Y6P5 / sestrin 1  / reaction / complex
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction






 

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