ENSG00000141564


Homo sapiens

Features
Gene ID: ENSG00000141564
  
Biological name :RPTOR
  
Synonyms : Q8N122 / regulatory associated protein of MTOR complex 1 / RPTOR
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.3
Gene start: 80544819
Gene end: 80966371
  
Corresponding Affymetrix probe sets: 225715_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000442479
Ensembl peptide - ENSP00000307272
Ensembl peptide - ENSP00000460136
Ensembl peptide - ENSP00000460940
Ensembl peptide - ENSP00000459701
NCBI entrez gene - 57521     See in Manteia.
OMIM - 607130
RefSeq - NM_020761
RefSeq - NM_001163034
RefSeq Peptide - NP_001156506
RefSeq Peptide - NP_065812
swissprot - Q8N122
swissprot - I3L2I3
swissprot - I3L436
Ensembl - ENSG00000141564
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rptorENSDARG00000098726Danio rerio
 RPTORENSGALG00000034210Gallus gallus
 RptorENSMUSG00000025583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000357  HEAT repeat
 IPR001680  WD40 repeat
 IPR004083  Regulatory associated protein of TOR
 IPR011989  Armadillo-like helical
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR029347  Raptor, N-terminal CASPase-like domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0009267 cellular response to starvation IBA
 biological_processGO:0010506 regulation of autophagy IBA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0031669 cellular response to nutrient levels IMP
 biological_processGO:0031929 TOR signaling IDA
 biological_processGO:0032008 positive regulation of TOR signaling IDA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0038202 TORC1 signaling IMP
 biological_processGO:0042325 regulation of phosphorylation IEA
 biological_processGO:0045945 positive regulation of transcription by RNA polymerase III IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IMP
 biological_processGO:0071233 cellular response to leucine IDA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IMP
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031931 TORC1 complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0001030 RNA polymerase III type 1 promoter DNA binding IDA
 molecular_functionGO:0001031 RNA polymerase III type 2 promoter DNA binding IDA
 molecular_functionGO:0001032 RNA polymerase III type 3 promoter DNA binding IDA
 molecular_functionGO:0001156 TFIIIC-class transcription factor binding IDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030291 protein serine/threonine kinase inhibitor activity IDA
 molecular_functionGO:0030295 protein kinase activator activity IDA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0071889 14-3-3 protein binding IDA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
HSF1-dependent transactivation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction / complex
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / complex / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / reaction / complex
 ENSG00000179632 MAF1 / Q9H063 / MAF1 homolog, negative regulator of RNA polymerase III  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction / complex
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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