ENSG00000204673


Homo sapiens

Features
Gene ID: ENSG00000204673
  
Biological name :AKT1S1
  
Synonyms : AKT1S1 / AKT1 substrate 1 / Q96B36
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.33
Gene start: 49869033
Gene end: 49878459
  
Corresponding Affymetrix probe sets: 1555821_a_at (Human Genome U133 Plus 2.0 Array)   224982_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000375711
Ensembl peptide - ENSP00000375710
Ensembl peptide - ENSP00000472839
Ensembl peptide - ENSP00000341698
Ensembl peptide - ENSP00000375706
Ensembl peptide - ENSP00000375707
Ensembl peptide - ENSP00000375708
Ensembl peptide - ENSP00000375709
NCBI entrez gene - 84335     See in Manteia.
OMIM - 610221
RefSeq - NM_001098633
RefSeq - NM_001278160
RefSeq - NM_032375
RefSeq - NM_001098632
RefSeq - NM_001278159
RefSeq Peptide - NP_001092103
RefSeq Peptide - NP_001265089
RefSeq Peptide - NP_115751
RefSeq Peptide - NP_001092102
RefSeq Peptide - NP_001265088
swissprot - Q96B36
swissprot - A0A024QZF6
swissprot - H9KV91
swissprot - M0R2V8
Ensembl - ENSG00000204673
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt1s1ENSDARG00000074667Danio rerio
 Akt1s1ENSMUSG00000011096Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026682  Proline-rich AKT1 substrate 1 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IDA
 biological_processGO:0032007 negative regulation of TOR signaling IDA
 biological_processGO:0038202 TORC1 signaling IBA
 biological_processGO:0042981 regulation of apoptotic process ISS
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0043523 regulation of neuron apoptotic process ISS
 biological_processGO:0045792 negative regulation of cell size IDA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031931 TORC1 complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
mTOR signalling
mTORC1-mediated signalling
AKT phosphorylates targets in the cytosol
HSF1-dependent transactivation
Constitutive Signaling by AKT1 E17K in Cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / complex
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / complex / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / complex / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex






 

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