ENSMUSG00000011096


Mus musculus

Features
Gene ID: ENSMUSG00000011096
  
Biological name :Akt1s1
  
Synonyms : Akt1s1 / Proline-rich AKT1 substrate 1 / Q9D1F4
  
Possible biological names infered from orthology : AKT1 substrate 1 / Q96B36
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 44848991
Gene end: 44855421
  
Corresponding Affymetrix probe sets: 10552752 (MoGene1.0st)   10552758 (MoGene1.0st)   1428158_at (Mouse Genome 430 2.0 Array)   1437736_at (Mouse Genome 430 2.0 Array)   1452684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103514
Ensembl peptide - ENSMUSP00000147235
Ensembl peptide - ENSMUSP00000146484
Ensembl peptide - ENSMUSP00000146332
Ensembl peptide - ENSMUSP00000122607
Ensembl peptide - ENSMUSP00000120690
Ensembl peptide - ENSMUSP00000116541
Ensembl peptide - ENSMUSP00000116149
Ensembl peptide - ENSMUSP00000103517
Ensembl peptide - ENSMUSP00000049764
Ensembl peptide - ENSMUSP00000103512
NCBI entrez gene - 67605     See in Manteia.
MGI - MGI:1914855
RefSeq - XM_006541122
RefSeq - NM_001253920
RefSeq - NM_001290694
RefSeq - NM_001290695
RefSeq - NM_026270
RefSeq - XM_006541115
RefSeq - XM_006541117
RefSeq - XM_006541118
RefSeq - XM_006541119
RefSeq - XM_006541120
RefSeq - XM_006541121
RefSeq Peptide - NP_001240849
RefSeq Peptide - NP_001277623
RefSeq Peptide - NP_001277624
RefSeq Peptide - NP_080546
swissprot - D3YWZ1
swissprot - Q9D1F4
swissprot - A0A140LHN7
swissprot - A0A140LHA0
swissprot - F6R8S6
swissprot - E9QKI4
swissprot - A0A140LJJ3
swissprot - E9QKI5
swissprot - D3Z4W3
swissprot - D3Z4R0
Ensembl - ENSMUSG00000011096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akt1s1ENSDARG00000074667Danio rerio
 AKT1S1ENSG00000204673Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026682  Proline-rich AKT1 substrate 1 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007219 Notch signaling pathway ISA
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0038202 TORC1 signaling IBA
 biological_processGO:0042981 regulation of apoptotic process IDA
 biological_processGO:0043523 regulation of neuron apoptotic process IDA
 biological_processGO:0045792 negative regulation of cell size ISO
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031931 TORC1 complex IBA


Pathways (from Reactome)
Pathway description
mTOR signalling
mTORC1-mediated signalling
AKT phosphorylates targets in the cytosol
HSF1-dependent transactivation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003076 increased susceptibility to ischemic brain injury "increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mad2l2tm1Mpz/Mad2l2tm1Mpz,Tg(Prdm1-cre)1Masu/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mad2l2tm1Mpz/Mad2l2tm1Mpz,Tg(Prdm1-cre)1Masu/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000028945 Rheb / Q921J2 / Ras homolog enriched in brain / Q15382* / Ras homolog, mTORC1 binding*  / reaction / complex
 ENSMUSG00000028278 Rragd / Ras-related GTP binding D / Q9NQL2*  / complex / reaction
 ENSMUSG00000028646 Rragc / Q99K70 / Ras-related GTP-binding protein C / Q9HB90* / Ras related GTP binding C*  / reaction / complex
 ENSMUSG00000041658 Rragb / Q6NTA4 / Ras-related GTP-binding protein B / Q5VZM2* / Ras related GTP binding B*  / reaction / complex
 ENSMUSG00000047789 Q8BGD6 / Slc38a9 / Sodium-coupled neutral amino acid transporter 9 / Q8NBW4* / solute carrier family 38 member 9*  / complex / reaction
 ENSMUSG00000070934 Rraga / Q80X95 / Ras-related GTP-binding protein A / Q7L523* / Ras related GTP binding A*  / complex / reaction
 ENSMUSG00000024142 Mlst8 / Q9DCJ1 / Target of rapamycin complex subunit LST8 / Q9BVC4* / MTOR associated protein, LST8 homolog*  / complex / reaction
 ENSMUSG00000011096 Akt1s1 / Q9D1F4 / Proline-rich AKT1 substrate 1 / Q96B36* / AKT1 substrate 1*  / complex
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / complex / reaction






 

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