ENSG00000106615


Homo sapiens

Features
Gene ID: ENSG00000106615
  
Biological name :RHEB
  
Synonyms : Q15382 / Ras homolog, mTORC1 binding / RHEB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q36.1
Gene start: 151466012
Gene end: 151520120
  
Corresponding Affymetrix probe sets: 1555780_a_at (Human Genome U133 Plus 2.0 Array)   201452_at (Human Genome U133 Plus 2.0 Array)   201453_x_at (Human Genome U133 Plus 2.0 Array)   213404_s_at (Human Genome U133 Plus 2.0 Array)   213409_s_at (Human Genome U133 Plus 2.0 Array)   227633_at (Human Genome U133 Plus 2.0 Array)   241795_at (Human Genome U133 Plus 2.0 Array)   243008_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262187
Ensembl peptide - ENSP00000420726
Ensembl peptide - ENSP00000418161
Ensembl peptide - ENSP00000417802
Ensembl peptide - ENSP00000417212
NCBI entrez gene - 6009     See in Manteia.
OMIM - 601293
RefSeq - NM_005614
RefSeq - XM_011516457
RefSeq Peptide - NP_005605
swissprot - Q15382
swissprot - F8WBL3
swissprot - C9J469
swissprot - A0A090N900
swissprot - C9J931
Ensembl - ENSG00000106615
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhebENSDARG00000090213Danio rerio
 RHEBENSGALG00000039880Gallus gallus
 RhebENSMUSG00000028945Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TAI7 / RHEBL1 / RHEB like 1ENSG0000016755052


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037586  GTP-binding protein Rheb


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:2000074 regulation of type B pancreatic cell development IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IMP
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction / complex
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000179632 MAF1 / Q9H063 / MAF1 homolog, negative regulator of RNA polymerase III  / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / reaction / complex
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / complex / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / reaction / complex
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction / complex
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / reaction / complex
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / complex / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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