ENSG00000116954


Homo sapiens

Features
Gene ID: ENSG00000116954
  
Biological name :RRAGC
  
Synonyms : Q9HB90 / Ras related GTP binding C / RRAGC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.3
Gene start: 38838198
Gene end: 38859823
  
Corresponding Affymetrix probe sets: 218088_s_at (Human Genome U133 Plus 2.0 Array)   222514_at (Human Genome U133 Plus 2.0 Array)   242531_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362092
NCBI entrez gene - 64121     See in Manteia.
OMIM - 608267
RefSeq - NM_022157
RefSeq - NM_001271851
RefSeq Peptide - NP_001258780
RefSeq Peptide - NP_071440
swissprot - Q9HB90
Ensembl - ENSG00000116954
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rragcaENSDARG00000069829Danio rerio
 RRAGCENSGALG00000033079Gallus gallus
 RragcENSMUSG00000028646Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RRAGD / Q9NQL2 / Ras related GTP binding DENSG0000002503976


Protein motifs (from Interpro)
Interpro ID Name
 IPR006762  Gtr1/RagA G protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006915 apoptotic process NAS
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0008380 RNA splicing NAS
 biological_processGO:0010506 regulation of autophagy IBA
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0032006 regulation of TOR signaling IGI
 biological_processGO:0032008 positive regulation of TOR signaling IBA
 biological_processGO:0034198 cellular response to amino acid starvation IGI
 biological_processGO:0034613 cellular protein localization ISS
 biological_processGO:0043200 response to amino acid IMP
 biological_processGO:0071230 cellular response to amino acid stimulus IBA
 biological_processGO:1903432 regulation of TORC1 signaling IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034448 EGO complex IBA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:1990131 Gtr1-Gtr2 GTPase complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding NAS
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0019003 GDP binding IMP
 molecular_functionGO:0046982 protein heterodimerization activity IMP
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / complex / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / reaction / complex
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / complex / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / complex / reaction
 ENSG00000204673 AKT1S1 / Q96B36 / AKT1 substrate 1  / complex / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / complex / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000166913 YWHAB / P31946 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta  / reaction / complex
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / complex / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / complex / reaction
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / complex / reaction
 ENSG00000179632 MAF1 / Q9H063 / MAF1 homolog, negative regulator of RNA polymerase III  / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / complex / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr