ENSG00000181929


Homo sapiens

Features
Gene ID: ENSG00000181929
  
Biological name :PRKAG1
  
Synonyms : P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.12
Gene start: 49002274
Gene end: 49019197
  
Corresponding Affymetrix probe sets: 201805_at (Human Genome U133 Plus 2.0 Array)   227527_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450112
Ensembl peptide - ENSP00000449637
Ensembl peptide - ENSP00000450273
Ensembl peptide - ENSP00000323867
Ensembl peptide - ENSP00000446987
Ensembl peptide - ENSP00000447433
Ensembl peptide - ENSP00000447637
Ensembl peptide - ENSP00000447671
Ensembl peptide - ENSP00000448251
Ensembl peptide - ENSP00000448290
Ensembl peptide - ENSP00000448739
Ensembl peptide - ENSP00000448873
Ensembl peptide - ENSP00000448972
Ensembl peptide - ENSP00000449104
Ensembl peptide - ENSP00000449121
NCBI entrez gene - 5571     See in Manteia.
OMIM - 602742
RefSeq - XM_017019623
RefSeq - NM_001206709
RefSeq - NM_001206710
RefSeq - NM_002733
RefSeq - XM_005269019
RefSeq - XM_005269020
RefSeq - XM_006719499
RefSeq - XM_011538562
RefSeq - XM_017019622
RefSeq Peptide - NP_001193639
RefSeq Peptide - NP_002724
RefSeq Peptide - NP_001193638
swissprot - H0YIC9
swissprot - P54619
swissprot - A0A024R125
swissprot - F8VPF5
swissprot - F8VQQ1
swissprot - F8VRY2
swissprot - F8VSH3
swissprot - F8VSL2
swissprot - F8VVA3
swissprot - F8VYY9
swissprot - F8VZX1
swissprot - F8VYZ8
swissprot - F8W046
swissprot - H0YHF8
Ensembl - ENSG00000181929
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkag1ENSDARG00000003818Danio rerio
 ENSGALG00000036282Gallus gallus
 O54950ENSMUSG00000067713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2ENSG0000010661770
PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3ENSG0000011559258


Protein motifs (from Interpro)
Interpro ID Name
 IPR000644  CBS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006110 regulation of glycolytic process TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0016236 macroautophagy TAS
 biological_processGO:0016241 regulation of macroautophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity TAS
 biological_processGO:0051170 import into nucleus IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004679 AMP-activated protein kinase activity ISS
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity TAS
 molecular_functionGO:0016208 AMP binding ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0043531 ADP binding ISS


Pathways (from Reactome)
Pathway description
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / complex / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / complex
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / reaction
 ENSG00000116954 RRAGC / Q9HB90 / Ras related GTP binding C  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction / complex
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / reaction
 ENSG00000155876 RRAGA / Q7L523 / Ras related GTP binding A  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction / complex
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / complex / reaction
 ENSG00000103197 TSC2 / P49815 / TSC complex subunit 2  / reaction
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / reaction
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / complex
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / reaction
 ENSG00000130766 SESN2 / P58004 / sestrin 2  / reaction / complex
 ENSG00000177058 Q8NBW4 / SLC38A9 / solute carrier family 38 member 9  / reaction
 ENSG00000165699 TSC1 / Q92574 / TSC complex subunit 1  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000198793 MTOR / P42345 / mechanistic target of rapamycin kinase  / reaction
 ENSG00000025039 RRAGD / Q9NQL2 / Ras related GTP binding D  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / reaction
 ENSG00000141564 RPTOR / Q8N122 / regulatory associated protein of MTOR complex 1  / reaction
 ENSG00000083750 RRAGB / Q5VZM2 / Ras related GTP binding B  / reaction
 ENSG00000106615 RHEB / Q15382 / Ras homolog, mTORC1 binding  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / reaction
 ENSG00000167965 MLST8 / Q9BVC4 / MTOR associated protein, LST8 homolog  / reaction
 ENSG00000080546 SESN1 / Q9Y6P5 / sestrin 1  / reaction / complex
 ENSG00000100614 PPM1A / P35813 / protein phosphatase, Mg2+/Mn2+ dependent 1A  / reaction
 ENSG00000118046 STK11 / Q15831 / serine/threonine kinase 11  / reaction






 

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