ENSG00000078142


Homo sapiens

Features
Gene ID: ENSG00000078142
  
Biological name :PIK3C3
  
Synonyms : phosphatidylinositol 3-kinase catalytic subunit type 3 / PIK3C3 / Q8NEB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q12.3
Gene start: 41955206
Gene end: 42087830
  
Corresponding Affymetrix probe sets: 1569272_at (Human Genome U133 Plus 2.0 Array)   204297_at (Human Genome U133 Plus 2.0 Array)   215394_at (Human Genome U133 Plus 2.0 Array)   229705_at (Human Genome U133 Plus 2.0 Array)   232086_at (Human Genome U133 Plus 2.0 Array)   239300_at (Human Genome U133 Plus 2.0 Array)   241304_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466946
Ensembl peptide - ENSP00000492528
Ensembl peptide - ENSP00000473061
Ensembl peptide - ENSP00000472926
Ensembl peptide - ENSP00000471957
Ensembl peptide - ENSP00000262039
Ensembl peptide - ENSP00000381845
Ensembl peptide - ENSP00000464909
Ensembl peptide - ENSP00000465621
NCBI entrez gene - 5289     See in Manteia.
OMIM - 602609
RefSeq - NM_001308020
RefSeq - NM_002647
RefSeq - XM_011526031
RefSeq Peptide - NP_001294949
RefSeq Peptide - NP_002638
swissprot - A8MYT4
swissprot - M0R386
swissprot - Q8NEB9
swissprot - M0R308
swissprot - A0A1W2PS05
swissprot - A0A0B4J2B1
swissprot - K7EIV6
swissprot - K7EKH3
swissprot - K7ENH3
Ensembl - ENSG00000078142
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3c3ENSDARG00000054829Danio rerio
 PIK3C3ENSGALG00000035773Gallus gallus
 Pik3c3ENSMUSG00000033628Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaENSG0000005138224
O00750 / PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaENSG0000013305623
O00443 / PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaENSG0000001140523
O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaENSG0000017160823
P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaENSG0000010585122
P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaENSG0000012187922
O75747 / PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaENSG0000013914421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006497 protein lipidation IMP
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0030242 autophagy of peroxisome IBA
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0034497 protein localization to phagophore assembly site IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0043201 response to leucine IEA
 biological_processGO:0045022 early endosome to late endosome transport IMP
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0050708 regulation of protein secretion IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000407 phagophore assembly site IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005777 peroxisome IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034271 phosphatidylinositol 3-kinase complex, class III, type I IBA
 cellular_componentGO:0034272 phosphatidylinositol 3-kinase complex, class III, type II IBA
 cellular_componentGO:0035032 phosphatidylinositol 3-kinase complex, class III IEA
 cellular_componentGO:0044754 autolysosome IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Macroautophagy
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Toll Like Receptor 9 (TLR9) Cascade
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000023287 Q8TDY2 / RB1CC1 / RB1 inducible coiled-coil 1  / reaction
 ENSG00000111725 PRKAB1 / Q9Y478 / protein kinase AMP-activated non-catalytic subunit beta 1  / reaction
 ENSG00000126775 ATG14 / Q6ZNE5 / autophagy related 14  / complex
 ENSG00000131791 O43741 / PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2  / reaction
 ENSG00000115592 PRKAG3 / Q9UGI9 / protein kinase AMP-activated non-catalytic subunit gamma 3  / reaction
 ENSG00000264364 DYNLL2 / Q96FJ2 / dynein light chain LC8-type 2  / complex / reaction
 ENSG00000088986 DYNLL1 / P63167 / dynein light chain LC8-type 1  / complex / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000126581 BECN1 / Q14457 / beclin 1  / complex
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / complex
 ENSG00000110497 AMBRA1 / Q9C0C7 / autophagy and beclin 1 regulator 1  / complex / reaction
 ENSG00000106617 PRKAG2 / Q9UGJ0 / protein kinase AMP-activated non-catalytic subunit gamma 2  / reaction
 ENSG00000132356 PRKAA1 / Q13131 / protein kinase AMP-activated catalytic subunit alpha 1  / reaction
 ENSG00000181929 P54619 / PRKAG1 / protein kinase AMP-activated non-catalytic subunit gamma 1  / reaction
 ENSG00000123395 ATG101 / Q9BSB4 / autophagy related 101  / reaction
 ENSG00000177169 ULK1 / O75385 / unc-51 like autophagy activating kinase 1  / reaction
 ENSG00000175224 ATG13 / O75143 / autophagy related 13  / reaction
 ENSG00000198382 UVRAG / Q9P2Y5 / UV radiation resistance associated  / complex
 ENSG00000162409 P54646 / PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2  / reaction






 

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