ENSG00000133056


Homo sapiens

Features
Gene ID: ENSG00000133056
  
Biological name :PIK3C2B
  
Synonyms : O00750 / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / PIK3C2B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 204422628
Gene end: 204494724
  
Corresponding Affymetrix probe sets: 204484_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356152
Ensembl peptide - ENSP00000400561
Ensembl peptide - ENSP00000401795
Ensembl peptide - ENSP00000409554
Ensembl peptide - ENSP00000356155
NCBI entrez gene - 5287     See in Manteia.
OMIM - 602838
RefSeq - XM_017001475
RefSeq - NM_002646
RefSeq - XM_005245257
RefSeq - XM_005245258
RefSeq - XM_011509630
RefSeq - XM_011509631
RefSeq - XM_017001473
RefSeq - XM_017001474
RefSeq Peptide - NP_002637
swissprot - A2RUF7
swissprot - F5GWN5
swissprot - Q5SW97
swissprot - Q5SW98
swissprot - Q5SWA0
swissprot - O00750
Ensembl - ENSG00000133056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3c2bENSDARG00000086927Danio rerio
 PIK3C2BENSGALG00000037043Gallus gallus
 Pik3c2bENSMUSG00000026447Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00443 / PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaENSG0000001140546
O75747 / PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaENSG0000013914432
O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaENSG0000017160817
P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaENSG0000010585117
P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaENSG0000005138217
P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaENSG0000012187916
PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3ENSG0000007814212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR001683  Phox homologous domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036871  PX domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0008150 biological_process ND
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0016236 macroautophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:1905037 autophagosome organization IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001727 lipid kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity NAS
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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