ENSG00000011405


Homo sapiens

Features
Gene ID: ENSG00000011405
  
Biological name :PIK3C2A
  
Synonyms : O00443 / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / PIK3C2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.1
Gene start: 17077730
Gene end: 17207983
  
Corresponding Affymetrix probe sets: 1553694_a_at (Human Genome U133 Plus 2.0 Array)   1569021_at (Human Genome U133 Plus 2.0 Array)   1569022_a_at (Human Genome U133 Plus 2.0 Array)   1569587_at (Human Genome U133 Plus 2.0 Array)   1569588_x_at (Human Genome U133 Plus 2.0 Array)   213070_at (Human Genome U133 Plus 2.0 Array)   226094_at (Human Genome U133 Plus 2.0 Array)   235792_x_at (Human Genome U133 Plus 2.0 Array)   241905_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436244
Ensembl peptide - ENSP00000436969
Ensembl peptide - ENSP00000265970
NCBI entrez gene - 5286     See in Manteia.
OMIM - 603601
RefSeq - XM_017017924
RefSeq - NM_001321378
RefSeq - NM_001321380
RefSeq - NM_002645
RefSeq - XM_011520186
RefSeq Peptide - NP_001308309
RefSeq Peptide - NP_002636
RefSeq Peptide - NP_001308307
swissprot - O00443
swissprot - E9PPP3
swissprot - A0A0C4DGF9
swissprot - L7RRS0
Ensembl - ENSG00000011405
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3c2aENSDARG00000060841Danio rerio
 PIK3C2AENSGALG00000006121Gallus gallus
 Pik3c2aENSMUSG00000030660Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00750 / PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaENSG0000013305645
O75747 / PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaENSG0000013914430
P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaENSG0000010585118
O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaENSG0000017160817
P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaENSG0000005138217
P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaENSG0000012187916
PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3ENSG0000007814212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR001683  Phox homologous domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036871  PX domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006887 exocytosis TAS
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0008286 insulin receptor signaling pathway TAS
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0014829 vascular smooth muscle contraction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway TAS
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0048268 clathrin coat assembly TAS
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity TAS
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity TAS
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
Synthesis of PIPs at the Golgi membrane
Synthesis of PIPs at the early endosome membrane
Synthesis of PIPs at the late endosome membrane
Golgi Associated Vesicle Biogenesis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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