ENSG00000105851


Homo sapiens

Features
Gene ID: ENSG00000105851
  
Biological name :PIK3CG
  
Synonyms : P48736 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma / PIK3CG
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.3
Gene start: 106865278
Gene end: 106907145
  
Corresponding Affymetrix probe sets: 206369_s_at (Human Genome U133 Plus 2.0 Array)   206370_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417623
Ensembl peptide - ENSP00000419260
Ensembl peptide - ENSP00000352121
Ensembl peptide - ENSP00000392258
NCBI entrez gene - 5294     See in Manteia.
OMIM - 601232
RefSeq - XM_017012328
RefSeq - NM_001282426
RefSeq - NM_001282427
RefSeq - NM_002649
RefSeq - XM_005250443
RefSeq - XM_011516316
RefSeq - XM_011516317
RefSeq Peptide - NP_002640
RefSeq Peptide - NP_001269355
RefSeq Peptide - NP_001269356
swissprot - E9PDN7
swissprot - P48736
swissprot - A0A024R720
Ensembl - ENSG00000105851
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cgENSDARG00000017757Danio rerio
 PIK3CGENSGALG00000008081Gallus gallus
 Pik3cgENSMUSG00000020573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaENSG0000012187930
O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaENSG0000017160829
P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit betaENSG0000005138229
O00443 / PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaENSG0000001140527
O00750 / PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaENSG0000013305625
O75747 / PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaENSG0000013914423
PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3ENSG0000007814217


Protein motifs (from Interpro)
Interpro ID Name
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001816 cytokine production TAS
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002250 adaptive immune response TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0002679 respiratory burst involved in defense response TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010818 T cell chemotaxis TAS
 biological_processGO:0010897 negative regulation of triglyceride catabolic process IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IDA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030593 neutrophil chemotaxis TAS
 biological_processGO:0032252 secretory granule localization IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin TAS
 biological_processGO:0035747 natural killer cell chemotaxis TAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042098 T cell proliferation TAS
 biological_processGO:0042110 T cell activation TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043303 mast cell degranulation TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0055118 negative regulation of cardiac muscle contraction TAS
 biological_processGO:0070527 platelet aggregation TAS
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0072672 neutrophil extravasation TAS
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035004 phosphatidylinositol 3-kinase activity TAS
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141506 PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5  / complex
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000185950 IRS2 / Q9Y4H2 / insulin receptor substrate 2  / reaction / complex
 ENSG00000187266 EPOR / P19235 / erythropoietin receptor  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000109458 GAB1 / Q13480 / GRB2 associated binding protein 1  / complex / reaction
 ENSG00000130427 EPO / P01588 / erythropoietin  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000276231 PIK3R6 / Q5UE93 / phosphoinositide-3-kinase regulatory subunit 6  / complex






 

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