ENSG00000276231


Homo sapiens

Features
Gene ID: ENSG00000276231
  
Biological name :PIK3R6
  
Synonyms : phosphoinositide-3-kinase regulatory subunit 6 / PIK3R6 / Q5UE93
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.1
Gene start: 8802723
Gene end: 8867677
  
Corresponding Affymetrix probe sets: 1558770_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484155
Ensembl peptide - ENSP00000480157
Ensembl peptide - ENSP00000480685
Ensembl peptide - ENSP00000482341
NCBI entrez gene - 146850     See in Manteia.
OMIM - 611462
RefSeq - XM_017024231
RefSeq - NM_001010855
RefSeq - NM_001290211
RefSeq - XM_011523683
RefSeq - XM_017024228
RefSeq - XM_017024229
RefSeq - XM_017024230
RefSeq - XM_011523677
RefSeq - XM_011523678
RefSeq - XM_011523680
RefSeq - XM_011523681
RefSeq Peptide - NP_001010855
RefSeq Peptide - NP_001277140
swissprot - Q5UE93
swissprot - A0A087X1F3
Ensembl - ENSG00000276231
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r6bENSDARG00000091140Danio rerio
 PIK3R6ENSGALG00000042351Gallus gallus
 Pik3r6ENSMUSG00000046207Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5ENSG0000014150624


Protein motifs (from Interpro)
Interpro ID Name
 IPR019522  Phosphoinositide 3-kinase regulatory subunit 5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0042269 regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB ISS
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity ISS


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105851 P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma  / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction






 

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