ENSMUSG00000046207


Mus musculus

Features
Gene ID: ENSMUSG00000046207
  
Biological name :Pik3r6
  
Synonyms : Phosphoinositide 3-kinase regulatory subunit 6 / Pik3r6 / Q3U6Q4
  
Possible biological names infered from orthology : Q5UE93
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 68503019
Gene end: 68552698
  
Corresponding Affymetrix probe sets: 10377286 (MoGene1.0st)   1437956_at (Mouse Genome 430 2.0 Array)   1443816_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052522
Ensembl peptide - ENSMUSP00000099673
NCBI entrez gene - 104709     See in Manteia.
MGI - MGI:2144613
RefSeq - XM_017314217
RefSeq - NM_001004435
RefSeq - NM_001081566
RefSeq - XM_006531948
RefSeq - XM_006531950
RefSeq Peptide - NP_001004435
RefSeq Peptide - NP_001075035
swissprot - Q3U6Q4
Ensembl - ENSMUSG00000046207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r6bENSDARG00000091140Danio rerio
 PIK3R6ENSGALG00000042351Gallus gallus
 PIK3R6ENSG00000276231Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3r5 / Q5SW28 / Phosphoinositide 3-kinase regulatory subunit 5 / Q8WYR1*ENSMUSG0000002090124


Protein motifs (from Interpro)
Interpro ID Name
 IPR019522  Phosphoinositide 3-kinase regulatory subunit 5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0042269 regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045582 positive regulation of T cell differentiation IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IDA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000020573 Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*  / complex






 

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