ENSMUSG00000020901


Mus musculus

Features
Gene ID: ENSMUSG00000020901
  
Biological name :Pik3r5
  
Synonyms : Phosphoinositide 3-kinase regulatory subunit 5 / Pik3r5 / Q5SW28
  
Possible biological names infered from orthology : Q8WYR1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 68432121
Gene end: 68497849
  
Corresponding Affymetrix probe sets: 10377265 (MoGene1.0st)   1434980_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021283
NCBI entrez gene - 320207     See in Manteia.
MGI - MGI:2443588
RefSeq - XM_006533548
RefSeq - NM_177320
RefSeq Peptide - NP_796294
swissprot - Q5SW28
swissprot - A1A4T4
Ensembl - ENSMUSG00000020901
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r5ENSDARG00000102762Danio rerio
 PIK3R5ENSGALG00000026167Gallus gallus
 PIK3R5ENSG00000141506Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3r6 / Q3U6Q4 / Phosphoinositide 3-kinase regulatory subunit 6 / Q5UE93*ENSMUSG0000004620721


Protein motifs (from Interpro)
Interpro ID Name
 IPR019522  Phosphoinositide 3-kinase regulatory subunit 5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB ISS
 cellular_componentGO:0016020 membrane ISS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding ISS
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oprk1tm1.2Waca/Oprk1tm1.2Waca
Genetic Background: B6J.B6NTac(Cg)-Oprk1tm1.2Waca

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r5tm1Lste/Pik3r5tm1Lste
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000020573 Pik3cg / Q9JHG7 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / P48736* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma*  / complex






 

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