ENSMUSG00000020573


Mus musculus

Features
Gene ID: ENSMUSG00000020573
  
Biological name :Pik3cg
  
Synonyms : Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / Pik3cg / Q9JHG7
  
Possible biological names infered from orthology : P48736 / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A3
Gene start: 32173473
Gene end: 32208659
  
Corresponding Affymetrix probe sets: 10399924 (MoGene1.0st)   1422707_at (Mouse Genome 430 2.0 Array)   1422708_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082596
Ensembl peptide - ENSMUSP00000151400
Ensembl peptide - ENSMUSP00000152007
Ensembl peptide - ENSMUSP00000062864
Ensembl peptide - ENSMUSP00000123539
NCBI entrez gene - 30955     See in Manteia.
MGI - MGI:1353576
RefSeq - XM_006515113
RefSeq - NM_001146200
RefSeq - NM_001146201
RefSeq - NM_020272
RefSeq - XM_006515112
RefSeq Peptide - NP_001139673
RefSeq Peptide - NP_064668
RefSeq Peptide - NP_001139672
swissprot - Q9JHG7
swissprot - A0A1W2P8F6
Ensembl - ENSMUSG00000020573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cgENSDARG00000017757Danio rerio
 PIK3CGENSGALG00000008081Gallus gallus
 P48736ENSG00000105851Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*ENSMUSG0000003246230
P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*ENSMUSG0000002766530
O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*ENSMUSG0000003993629
Pik3c2a / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSMUSG0000003066028
Pik3c2b / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSMUSG0000002644725
Pik3c2g / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 / O75747* / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma*ENSMUSG0000003022819
Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*ENSMUSG0000003362817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR008290  Phosphatidylinositol 3-kinase, Vps34 type
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010818 T cell chemotaxis IBA
 biological_processGO:0010897 negative regulation of triglyceride catabolic process IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0032252 secretory granule localization IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0070527 platelet aggregation IBA
 biological_processGO:0071320 cellular response to cAMP IMP
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IMP
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB ISO
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046875 ephrin receptor binding ISO
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Ghrtm1Jjk/Ghrtm1Jjk
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002367 abnormal thymus lobule morphology "anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnab1tm1Mes/Kcnab1+,Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnab1tm1Mes/Kcnab1+,Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd81tm1Lvy/Cd81tm1Lvy
Genetic Background: CByJ.129-Cd81tm1Lvy

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pik3cbtm1a(EUCOMM)Wtsi/Pik3cbtm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Pik3cbtm1a(EUCOMM)Wtsi/Wtsi

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Ptentm2.1Ppp/Ptentm2.1Ppp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6

 MP:0004867 decreased platelet calcium level "decreased concentration in the platelet of this bivalent element" [RGD:Rat Genome Database submission]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Apoetm1Unc Pik3cgtm1Dwu

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Apoetm1Unc Pik3cgtm1Dwu

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plcb3tm1Dwu/Plcb3tm1Dwu
Genetic Background: Not Specified

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005599 increased cardiac muscle contractility "greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr,Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Ace2tm1Pngr/Y,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Pik3cdtm1Jni/Pik3cdtm1Jni,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Kif3ctm1Gsn/Kif3ctm1Gsn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pik3cgtm2Ehi/Pik3cgtm2Ehi
Genetic Background: Not Specified

Allelic Composition: Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129P2-Pik3cgtm1Pngr

Allelic Composition: Pik3cdtm1Tnr/Pik3cdtm1Tnr,Pik3cgtm1Pngr/Pik3cgtm1Pngr
Genetic Background: B6.129-Pik3cdtm1Tnr Pik3cgtm1Pngr

Allelic Composition: Pik3cgtm1Lste/Pik3cgtm1Lste
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: Not Specified

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ntrk2tm1Jom/Ntrk2+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR

Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cgtm1Dwu/Pik3cgtm1Dwu
Genetic Background: B6.Cg-Pik3cgtm1Dwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000046207 Pik3r6 / Q3U6Q4 / Phosphoinositide 3-kinase regulatory subunit 6 / Q5UE93*  / complex
 ENSMUSG00000020901 Pik3r5 / Q5SW28 / Phosphoinositide 3-kinase regulatory subunit 5 / Q8WYR1*  / complex






 

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