ENSGALG00000008081


Gallus gallus

Features
Gene ID: ENSGALG00000008081
  
Biological name :PIK3CG
  
Synonyms : phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma / PIK3CG
  
Possible biological names infered from orthology : P48736 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform / Q9JHG7
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 14409032
Gene end: 14442571
  
Corresponding Affymetrix probe sets: GgaAffx.5073.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000013101
NCBI entrez gene - 417706     See in Manteia.
RefSeq - NM_001199538
RefSeq - XM_015275714
RefSeq - XM_015275715
RefSeq Peptide - NP_001186467
swissprot - E1C093
Ensembl - ENSGALG00000008081
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3cgENSDARG00000017757Danio rerio
 P48736ENSG00000105851Homo sapiens
 Pik3cgENSMUSG00000020573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *ENSGALG0000000893429
PIK3CD / phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform / O00329* / O35904* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta*ENSGALG0000000258329
PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *ENSGALG0000000550529
PIK3C2A / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha / O00443*ENSGALG0000000612127
PIK3C2B / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta / O00750*ENSGALG0000003704325
PIK3C2G / phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma / O75747* / phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 2 *ENSGALG0000001311721
PIK3C3 / phosphatidylinositol 3-kinase catalytic subunit type 3 / Q6PF93* / Q8NEB9*ENSGALG0000003577317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000341  Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
 IPR002420  Phosphatidylinositol 3-kinase, C2 domain
 IPR003113  Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
 IPR011009  Protein kinase-like domain superfamily
 IPR015433  Phosphatidylinositol kinase
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010818 T cell chemotaxis IBA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070527 platelet aggregation IBA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:1903169 regulation of calcium ion transmembrane transport IEA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005944 phosphatidylinositol 3-kinase complex, class IB IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Synthesis of PIPs at the plasma membrane
G beta:gamma signalling through PI3Kgamma


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001334 GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*  / reaction / complex
 ENSGALG00000027629 GNG2 / G protein subunit gamma 2 / P59768* / P63213* / guanine nucleotide binding protein (G protein), gamma 2*  / complex / reaction
 ENSGALG00000042351 PIK3R6 / phosphoinositide-3-kinase regulatory subunit 6 / Q3U6Q4* / Q5UE93*  / complex






 

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