Manteia

ENSG00000186469

Homo sapiens

Features

Gene ID:	ENSG00000186469

Biological name :	GNG2

Synonyms :	GNG2 / G protein subunit gamma 2 / P59768

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	14
Strand:	1
Band:	q22.1
Gene start:	51826195
Gene end:	51979342

Corresponding Affymetrix probe sets:	1555766_a_at (Human Genome U133 Plus 2.0 Array) 223943_s_at (Human Genome U133 Plus 2.0 Array) 224964_s_at (Human Genome U133 Plus 2.0 Array) 224965_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000484021 Ensembl peptide - ENSP00000451576 Ensembl peptide - ENSP00000452014 Ensembl peptide - ENSP00000334448 Ensembl peptide - ENSP00000450586 Ensembl peptide - ENSP00000450758 Ensembl peptide - ENSP00000450904 Ensembl peptide - ENSP00000451102 Ensembl peptide - ENSP00000451231 Ensembl peptide - ENSP00000451279 Ensembl peptide - ENSP00000451536 NCBI entrez gene - 54331 See in Manteia. OMIM - 606981 RefSeq - XM_017021377 RefSeq - NM_001243773 RefSeq - NM_001243774 RefSeq - NM_053064 RefSeq - XM_006720173 RefSeq - XM_011536846 RefSeq - XM_017021376 RefSeq Peptide - NP_001230703 RefSeq Peptide - NP_444292 RefSeq Peptide - NP_001230702 swissprot - G3V3J9 swissprot - G3V415 swissprot - G3V2C9 swissprot - P59768 swissprot - G3V2N0 swissprot - G3V2W5 Ensembl - ENSG00000186469

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gng2	ENSDARG00000056831	Danio rerio
GNG2	ENSGALG00000027629	Gallus gallus
Gng2	ENSMUSG00000043004	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
GNG4 / P50150 / G protein subunit gamma 4	ENSG00000168243	77
GNG3 / P63215 / G protein subunit gamma 3	ENSG00000162188	76
GNG8 / Q9UK08 / G protein subunit gamma 8	ENSG00000167414	69
GNG7 / O60262 / G protein subunit gamma 7	ENSG00000176533	68
GNG12 / Q9UBI6 / G protein subunit gamma 12	ENSG00000172380	61
GNG10 / P50151 / G protein subunit gamma 10	ENSG00000242616	51
GNG14 / A0A1W2PPG7 / G protein subunit gamma 14	ENSG00000283980	48
GNG5 / P63218 / G protein subunit gamma 5	ENSG00000174021	46

Protein motifs (from Interpro)

Interpro ID	Name
IPR001770	G-protein, gamma subunit
IPR015898	G-protein gamma-like domain
IPR036284	G-protein gamma-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006457	protein folding	TAS
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway	ISS
biological_process	GO:0007223	Wnt signaling pathway, calcium modulating pathway	TAS
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0030168	platelet activation	TAS
biological_process	GO:0071377	cellular response to glucagon stimulus	TAS
biological_process	GO:0071380	cellular response to prostaglandin E stimulus	ISS
biological_process	GO:0071870	cellular response to catecholamine stimulus	ISS
cellular_component	GO:0005834	heterotrimeric G-protein complex	ISS
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	ISS
cellular_component	GO:0070062	extracellular exosome	HDA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0031681	G-protein beta-subunit binding	IPI

Pathways (from Reactome)

Pathway description

Activation of G protein gated Potassium channels

Glucagon signaling in metabolic regulation

G-protein activation

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

ADP signalling through P2Y purinoceptor 12

G beta:gamma signalling through PI3Kgamma

Prostacyclin signalling through prostacyclin receptor

Adrenaline,noradrenaline inhibits insulin secretion

Ca2+ pathway

G alpha (q) signalling events

G alpha (12/13) signalling events

G beta:gamma signalling through PLC beta

G alpha (s) signalling events

ADP signalling through P2Y purinoceptor 1

G alpha (i) signalling events

G alpha (z) signalling events

Glucagon-type ligand receptors

Thromboxane signalling through TP receptor

Vasopressin regulates renal water homeostasis via Aquaporins

Thrombin signalling through proteinase activated receptors (PARs)

Presynaptic function of Kainate receptors

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000088256	GNA11 / P29992 / G protein subunit alpha 11	/ complex / reaction
ENSG00000111664	GNB3 / P16520 / G protein subunit beta 3	/ reaction / complex
ENSG00000114349	GNAT1 / P11488 / G protein subunit alpha transducin 1	/ complex
ENSG00000128617	OPN1SW / P03999 / opsin 1, short wave sensitive	/ complex / reaction
ENSG00000127533	F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3	/ complex / reaction
ENSG00000114450	GNB4 / Q9HAV0 / G protein subunit beta 4	/ reaction / complex
ENSG00000087460	GNAS / O95467 / Q5JWF2 / P63092 / P84996 / GNAS complex locus	/ complex / reaction
ENSG00000136940	PDCL / Q13371 / phosducin like	/ reaction / complex
ENSG00000060558	GNA15 / P30679 / G protein subunit alpha 15	/ complex / reaction
ENSG00000141506	PIK3R5 / Q8WYR1 / phosphoinositide-3-kinase regulatory subunit 5	/ complex / reaction
ENSG00000156052	GNAQ / P50148 / G protein subunit alpha q	/ complex / reaction
ENSG00000163914	RHO / P08100 / rhodopsin	/ complex / reaction
ENSG00000164220	F2RL2 / O00254 / coagulation factor II thrombin receptor like 2	/ complex / reaction
ENSG00000172354	GNB2 / P62879 / G protein subunit beta 2	/ reaction / complex
ENSG00000146535	GNA12 / Q03113 / G protein subunit alpha 12	/ complex / reaction
ENSG00000150594	ADRA2A / P08913 / adrenoceptor alpha 2A	/ reaction / complex
ENSG00000169860	P2RY1 / P47900 / purinergic receptor P2Y1	/ complex / reaction
ENSG00000160013	PTGIR / P43119 / prostaglandin I2 receptor	/ reaction / complex
ENSG00000181104	F2R / P25116 / coagulation factor II thrombin receptor	/ complex / reaction
ENSG00000156049	GNA14 / O95837 / G protein subunit alpha 14	/ complex / reaction
ENSG00000184160	ADRA2C / P18825 / adrenoceptor alpha 2C	/ complex / reaction
ENSG00000114353	GNAI2 / P04899 / G protein subunit alpha i2	/ reaction / complex
ENSG00000128266	GNAZ / P19086 / G protein subunit alpha z	/ reaction / complex
ENSG00000120063	GNA13 / Q14344 / G protein subunit alpha 13	/ complex / reaction
ENSG00000137841	PLCB2 / Q00722 / phospholipase C beta 2	/ reaction / complex
ENSG00000149782	PLCB3 / Q01970 / phospholipase C beta 3	/ reaction / complex
ENSG00000120907	ADRA1A / P35348 / adrenoceptor alpha 1A	/ complex / reaction
ENSG00000112038	OPRM1 / P35372 / opioid receptor mu 1	/ complex / reaction
ENSG00000115138	POMC / P01189 / proopiomelanocortin	/ reaction / complex
ENSG00000065135	GNAI3 / P08754 / G protein subunit alpha i3	/ complex / reaction
ENSG00000214415	GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3	/ reaction / complex
ENSG00000182621	PLCB1 / Q9NQ66 / phospholipase C beta 1	/ complex / reaction
ENSG00000006638	P21731 / TBXA2R / thromboxane A2 receptor	/ complex / reaction
ENSG00000170214	ADRA1B / P35368 / adrenoceptor alpha 1B	/ reaction / complex
ENSG00000169313	P2RY12 / Q9H244 / purinergic receptor P2Y12	/ complex / reaction
ENSG00000087258	GNAO1 / P09471 / G protein subunit alpha o1	/ complex
ENSG00000186469	GNG2 / P59768 / G protein subunit gamma 2	/ reaction
ENSG00000134183	GNAT2 / P19087 / G protein subunit alpha transducin 2	/ complex
ENSG00000127955	GNAI1 / P63096 / G protein subunit alpha i1	/ reaction / complex
ENSG00000101327	PDYN / P01213 / prodynorphin	/ reaction / complex
ENSG00000171873	ADRA1D / P25100 / adrenoceptor alpha 1D	/ reaction / complex
ENSG00000078369	GNB1 / P62873 / G protein subunit beta 1	/ complex / reaction
ENSG00000105851	P48736 / PIK3CG / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	/ complex / reaction
ENSG00000102076	OPN1LW / P04000 / opsin 1, long wave sensitive	/ reaction / complex
ENSG00000163873	GRIK3 / Q13003 / glutamate ionotropic receptor kainate type subunit 3	/ complex / reaction
ENSG00000268221	OPN1MW / P04001 / opsin 1, medium wave sensitive	/ complex / reaction
ENSG00000276231	PIK3R6 / Q5UE93 / phosphoinositide-3-kinase regulatory subunit 6	/ reaction / complex
ENSG00000274286	ADRA2B / P18089 / adrenoceptor alpha 2B	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr