ENSG00000120907


Homo sapiens

Features
Gene ID: ENSG00000120907
  
Biological name :ADRA1A
  
Synonyms : ADRA1A / adrenoceptor alpha 1A / P35348
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.2
Gene start: 26748150
Gene end: 26867273
  
Corresponding Affymetrix probe sets: 211489_at (Human Genome U133 Plus 2.0 Array)   211490_at (Human Genome U133 Plus 2.0 Array)   211491_at (Human Genome U133 Plus 2.0 Array)   211492_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430414
Ensembl peptide - ENSP00000369960
Ensembl peptide - ENSP00000430793
Ensembl peptide - ENSP00000431073
Ensembl peptide - ENSP00000276393
Ensembl peptide - ENSP00000346557
Ensembl peptide - ENSP00000369946
Ensembl peptide - ENSP00000369947
Ensembl peptide - ENSP00000369956
NCBI entrez gene - 148     See in Manteia.
OMIM - 104221
RefSeq - XM_017013095
RefSeq - NM_001322503
RefSeq - NM_001322504
RefSeq - NM_033302
RefSeq - NM_033303
RefSeq - NM_033304
RefSeq - XM_006716292
RefSeq - XM_006716293
RefSeq - XM_011544411
RefSeq - XM_017013094
RefSeq - NM_000680
RefSeq Peptide - NP_001309432
RefSeq Peptide - NP_001309433
RefSeq Peptide - NP_150645
RefSeq Peptide - NP_150646
RefSeq Peptide - NP_150647
RefSeq Peptide - NP_000671
swissprot - B0ZBD3
swissprot - E7EW16
swissprot - P35348
Ensembl - ENSG00000120907
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra1aaENSDARG00000028725Danio rerio
 adra1abENSDARG00000027638Danio rerio
 ADRA1AENSGALG00000000469Gallus gallus
 Adra1aENSMUSG00000045875Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021448
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187346
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868026
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909725
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428625
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416024
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839424
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883024
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059424
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531224
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954624
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721922


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001004  Alpha 1A adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA
 biological_processGO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA
 biological_processGO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
 biological_processGO:0003084 positive regulation of systemic arterial blood pressure IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006937 regulation of muscle contraction IEA
 biological_processGO:0006939 smooth muscle contraction TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0007568 aging ISS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic ISS
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISS
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042493 response to drug ISS
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045760 positive regulation of action potential ISS
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0060073 micturition IEA
 biological_processGO:0060402 calcium ion transport into cytosol ISS
 biological_processGO:0060452 positive regulation of cardiac muscle contraction ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISS
 biological_processGO:0097195 pilomotor reflex IEA
 biological_processGO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030315 T-tubule IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004937 alpha1-adrenergic receptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr