ENSG00000135312


Homo sapiens

Features
Gene ID: ENSG00000135312
  
Biological name :HTR1B
  
Synonyms : 5-hydroxytryptamine receptor 1B / HTR1B / P28222
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q14.1
Gene start: 77461753
Gene end: 77463773
  
Corresponding Affymetrix probe sets: 210799_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358963
NCBI entrez gene - 3351     See in Manteia.
OMIM - 182131
RefSeq - NM_000863
RefSeq Peptide - NP_000854
swissprot - P28222
swissprot - X5D7I5
Ensembl - ENSG00000135312
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr1bENSDARG00000053987Danio rerio
 HTR1BENSGALG00000015895Gallus gallus
 Htr1bENSMUSG00000049511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954661
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909745
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883045
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839442
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868034
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721933
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059431
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416031
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021430
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187330
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428629
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002147  5-Hydroxytryptamine 1B receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0014059 regulation of dopamine secretion IEA
 biological_processGO:0014063 negative regulation of serotonin secretion IEA
 biological_processGO:0032229 negative regulation of synaptic transmission, GABAergic IEA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0051385 response to mineralocorticoid IEA
 biological_processGO:0051967 negative regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0071312 cellular response to alkaloid IDA
 biological_processGO:0071502 cellular response to temperature stimulus IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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