ENSG00000171873


Homo sapiens

Features
Gene ID: ENSG00000171873
  
Biological name :ADRA1D
  
Synonyms : ADRA1D / adrenoceptor alpha 1D / P25100
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p13
Gene start: 4220631
Gene end: 4249074
  
Corresponding Affymetrix probe sets: 210960_at (Human Genome U133 Plus 2.0 Array)   210961_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368766
NCBI entrez gene - 146     See in Manteia.
OMIM - 104219
RefSeq - NM_000678
RefSeq Peptide - NP_000669
swissprot - B0ZBE0
swissprot - P25100
Ensembl - ENSG00000171873
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra1dENSDARG00000024101Danio rerio
 ENSGALG00000038787Gallus gallus
 Adra1dENSMUSG00000027335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021445
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090738
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868023
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839421
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416021
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428621
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531220
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059420
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954618
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909718
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883017
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000363  Alpha 1D adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA
 biological_processGO:0006259 DNA metabolic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0045907 positive regulation of vasoconstriction IBA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IBA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004937 alpha1-adrenergic receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction






 

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