ENSG00000178394


Homo sapiens

Features
Gene ID: ENSG00000178394
  
Biological name :HTR1A
  
Synonyms : 5-hydroxytryptamine receptor 1A / HTR1A / P08908
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q12.3
Gene start: 63960356
Gene end: 63962507
  
Corresponding Affymetrix probe sets: 221351_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000316244
Ensembl peptide - ENSP00000423433
NCBI entrez gene - 3350     See in Manteia.
OMIM - 109760
RefSeq - NM_000524
RefSeq Peptide - NP_000515
swissprot - D6RA34
swissprot - P08908
swissprot - Q5ZGX3
Ensembl - ENSG00000178394
  
Related genetic diseases (OMIM): 614674 - Periodic fever, menstrual cycle dependent, 614674
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr1aaENSDARG00000093745Danio rerio
 HTR1AENSGALG00000014742Gallus gallus
 Htr1aENSMUSG00000021721Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531239
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954637
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909736
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883034
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868030
ADRA2C / P18825 / adrenoceptor alpha 2CENSG0000018416030
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187329
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021429
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059429
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721929
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428628
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090727


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000610  5-Hydroxytryptamine 1A receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
 biological_processGO:0007210 serotonin receptor signaling pathway IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0014062 regulation of serotonin secretion IEA
 biological_processGO:0035640 exploration behavior IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042428 serotonin metabolic process IEA
 biological_processGO:0046883 regulation of hormone secretion IEA
 biological_processGO:0050795 regulation of behavior IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IBA
 molecular_functionGO:0090722 receptor-receptor interaction IDA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0001945 Fever 
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 HP:0002076 Migraine 
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 HP:0003118 Increased serum cortisol 
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 HP:0200067 Recurrent spontaneous abortion 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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