ENSG00000184160


Homo sapiens

Features
Gene ID: ENSG00000184160
  
Biological name :ADRA2C
  
Synonyms : ADRA2C / adrenoceptor alpha 2C / P18825
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p16.3
Gene start: 3766348
Gene end: 3768526
  
Corresponding Affymetrix probe sets: 206128_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386069
Ensembl peptide - ENSP00000426268
NCBI entrez gene - 152     See in Manteia.
OMIM - 104250
RefSeq - NM_000683
RefSeq Peptide - NP_000674
swissprot - D6RGL0
swissprot - P18825
swissprot - Q4W594
Ensembl - ENSG00000184160
  
Related genetic diseases (OMIM): 104250 - {Congestive heart failure and beta-blocker response, modifier of}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adra2cENSDARG00000069669Danio rerio
 ADRA2CENSGALG00000015608Gallus gallus
 Adra2cENSMUSG00000045318Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRA2A / P08913 / adrenoceptor alpha 2AENSG0000015059452
ADRA2B / P18089 / adrenoceptor alpha 2BENSG0000027428647
HTR1A / P08908 / 5-hydroxytryptamine receptor 1AENSG0000017839427
ADRA1B / P35368 / adrenoceptor alpha 1BENSG0000017021427
HTR1D / P28221 / 5-hydroxytryptamine receptor 1DENSG0000017954626
HTR1B / P28222 / 5-hydroxytryptamine receptor 1BENSG0000013531226
ADRA1D / P25100 / adrenoceptor alpha 1DENSG0000017187326
ADRA1A / P35348 / adrenoceptor alpha 1AENSG0000012090724
HTR1F / P30939 / 5-hydroxytryptamine receptor 1FENSG0000017909724
HTR7 / P34969 / 5-hydroxytryptamine receptor 7ENSG0000014868024
HTR5A / P47898 / 5-hydroxytryptamine receptor 5AENSG0000015721924
HTR1E / P28566 / 5-hydroxytryptamine receptor 1EENSG0000016883023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000735  Alpha 2C adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion TAS
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0032148 activation of protein kinase B activity IDA
 biological_processGO:0032811 negative regulation of epinephrine secretion NAS
 biological_processGO:0035625 obsolete epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045666 positive regulation of neuron differentiation IDA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0050796 regulation of insulin secretion TAS
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0070473 negative regulation of uterine smooth muscle contraction IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IDA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004938 alpha2-adrenergic receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051379 epinephrine binding IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000128266 GNAZ / P19086 / G protein subunit alpha z  / complex / reaction






 

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