ENSG00000128266


Homo sapiens

Features
Gene ID: ENSG00000128266
  
Biological name :GNAZ
  
Synonyms : GNAZ / G protein subunit alpha z / P19086
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.22
Gene start: 23070361
Gene end: 23125037
  
Corresponding Affymetrix probe sets: 204993_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478892
NCBI entrez gene - 2781     See in Manteia.
OMIM - 139160
RefSeq - NM_002073
RefSeq Peptide - NP_002064
swissprot - P19086
Ensembl - ENSG00000128266
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAZENSDARG00000099844Danio rerio
 GNAZENSGALG00000006719Gallus gallus
 GnazENSMUSG00000040009Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513567
GNAI1 / P63096 / G protein subunit alpha i1ENSG0000012795567
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435366
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725859
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3ENSG0000021441558
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418357
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434954
GNAQ / P50148 / G protein subunit alpha qENSG0000015605247
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604947
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825646
GNA15 / P30679 / G protein subunit alpha 15ENSG0000006055843
GNA12 / Q03113 / G protein subunit alpha 12ENSG0000014653540
GNA13 / Q14344 / G protein subunit alpha 13ENSG0000012006339


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031821 G-protein coupled serotonin receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150594 ADRA2A / P08913 / adrenoceptor alpha 2A  / reaction / complex
 ENSG00000184160 ADRA2C / P18825 / adrenoceptor alpha 2C  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000274286 ADRA2B / P18089 / adrenoceptor alpha 2B  / reaction / complex






 

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