ENSG00000127955


Homo sapiens

Features
Gene ID: ENSG00000127955
  
Biological name :GNAI1
  
Synonyms : GNAI1 / G protein subunit alpha i1 / P63096
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.11
Gene start: 80133955
Gene end: 80219402
  
Corresponding Affymetrix probe sets: 209576_at (Human Genome U133 Plus 2.0 Array)   227692_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388347
Ensembl peptide - ENSP00000410572
Ensembl peptide - ENSP00000391439
Ensembl peptide - ENSP00000389435
Ensembl peptide - ENSP00000343027
NCBI entrez gene - 2770     See in Manteia.
OMIM - 139310
RefSeq - NM_002069
RefSeq - NM_001256414
RefSeq Peptide - NP_001243343
RefSeq Peptide - NP_002060
swissprot - P63096
swissprot - C9JL77
swissprot - C9J2Z2
swissprot - C9JPP4
Ensembl - ENSG00000127955
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnai3ENSDARG00000030644Danio rerio
 GNAI1ENSGALG00000008382Gallus gallus
 Gnai1ENSMUSG00000057614Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513594
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435388
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725873
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418369
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3ENSG0000021441568
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434968
GNAZ / P19086 / G protein subunit alpha zENSG0000012826667
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604952
GNAQ / P50148 / G protein subunit alpha qENSG0000015605252
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825651
GNA15 / P30679 / G protein subunit alpha 15ENSG0000006055844
GNA12 / Q03113 / G protein subunit alpha 12ENSG0000014653541
GNA13 / Q14344 / G protein subunit alpha 13ENSG0000012006339


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0043434 response to peptide hormone ISS
 biological_processGO:0043949 regulation of cAMP-mediated signaling ISS
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051301 cell division IMP
 biological_processGO:0060236 regulation of mitotic spindle organization IMP
 biological_processGO:1904322 cellular response to forskolin ISS
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0001664 G-protein coupled receptor binding ISS
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0019003 GDP binding ISS
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0031821 G-protein coupled serotonin receptor binding IBA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Regulation of insulin secretion
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141404 GNAL / P38405 / G protein subunit alpha L  / complex / reaction
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000169313 P2RY12 / Q9H244 / purinergic receptor P2Y12  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex






 

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