ENSMUSG00000057614


Mus musculus

Features
Gene ID: ENSMUSG00000057614
  
Biological name :Gnai1
  
Synonyms : B2RSH2 / Gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting 1
  
Possible biological names infered from orthology : G protein subunit alpha i1 / P63096
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 18265135
Gene end: 18360355
  
Corresponding Affymetrix probe sets: 10528227 (MoGene1.0st)   1427510_at (Mouse Genome 430 2.0 Array)   1434440_at (Mouse Genome 430 2.0 Array)   1454959_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074259
NCBI entrez gene - 14677     See in Manteia.
MGI - MGI:95771
RefSeq - NM_010305
RefSeq Peptide - NP_034435
swissprot - B2RSH2
Ensembl - ENSMUSG00000057614
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnai3ENSDARG00000030644Danio rerio
 GNAI1ENSGALG00000008382Gallus gallus
 GNAI1ENSG00000127955Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000194
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256288
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174871
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910869
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483768
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000967
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877767
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463952
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478151
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469751
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479243
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014940
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061139


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0043949 regulation of cAMP-mediated signaling IEA
 biological_processGO:0050805 negative regulation of synaptic transmission IEA
 biological_processGO:0051301 cell division ISO
 biological_processGO:0060236 regulation of mitotic spindle organization IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 biological_processGO:1904778 positive regulation of protein localization to cell cortex IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0099738 cell cortex region IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISS
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0031821 G-protein coupled serotonin receptor binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
ADP signalling through P2Y purinoceptor 12
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnai1tm1Drs/Gnai1+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Pde6batrd3/Pde6batrd3
Genetic Background: involves: BALB/cAnN * C3H/HeN

Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnai1tm1Drs/Gnai1+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnai2tm1Lbi/Gnai2+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009818 abnormal thromboxane level 
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: DbnlGt(betageo)11Byg/DbnlGt(betageo)11Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gnai1tm1Drs/Gnai1+,Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024524 Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000036353 P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*  / complex / reaction






 

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