ENSMUSG00000031748


Mus musculus

Features
Gene ID: ENSMUSG00000031748
  
Biological name :Gnao1
  
Synonyms : Gnao1 / guanine nucleotide binding protein, alpha O / P18872
  
Possible biological names infered from orthology : G protein subunit alpha o1 / P09471
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 93809966
Gene end: 93969388
  
Corresponding Affymetrix probe sets: 10573979 (MoGene1.0st)   1421152_a_at (Mouse Genome 430 2.0 Array)   1448031_at (Mouse Genome 430 2.0 Array)   1460383_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148550
Ensembl peptide - ENSMUSP00000118463
Ensembl peptide - ENSMUSP00000119220
Ensembl peptide - ENSMUSP00000034198
Ensembl peptide - ENSMUSP00000114144
Ensembl peptide - ENSMUSP00000115007
Ensembl peptide - ENSMUSP00000116826
NCBI entrez gene - 14681     See in Manteia.
MGI - MGI:95775
RefSeq - XM_011248311
RefSeq - NM_001113384
RefSeq - NM_010308
RefSeq Peptide - NP_034438
RefSeq Peptide - NP_001106855
swissprot - D3Z2M7
swissprot - P18872
swissprot - F6WC15
swissprot - F6W1B2
swissprot - F7BLT7
swissprot - Q543S2
Ensembl - ENSMUSG00000031748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gnao1aENSDARG00000016676Danio rerio
 gnao1bENSDARG00000036058Danio rerio
 GNAO1ENSGALG00000003163Gallus gallus
 GNAO1ENSG00000087258Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761471
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000170
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256269
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877760
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483759
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910859
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000957
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469751
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478149
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463949
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479243
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*ENSMUSG0000000014941
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0009987 cellular process IMP
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0031821 G-protein coupled serotonin receptor binding IEA
 molecular_functionGO:0031852 mu-type opioid receptor binding IEA
 molecular_functionGO:0032794 GTPase activating protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051430 corticotropin-releasing hormone receptor 1 binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
Ca2+ pathway
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa-By/Eda+
Genetic Background: BALB/cBy

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
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Allelic Composition: Gnao1tm2.1Rneu/Gnao1+
Genetic Background: B6.129S-Gnao1tm2.1Rneu

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gnao1tm2.1Rneu/Gnao1+
Genetic Background: B6.129S-Gnao1tm2.1Rneu

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Gnao1tm2.1Rneu/Gnao1+
Genetic Background: B6.129S-Gnao1tm2.1Rneu

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv,Fat4tm1.1Hmc/Fat4tm1.1Hmc
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Sox10tm4Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd * C3H

Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm4Lbi/Gnao1tm4Lbi,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnao1tm2Lbi/Gnao1tm2Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gnao1tm4.1Lbi/Gnao1tm4.1Lbi
Genetic Background: Not Specified

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rapgef6tm1.1Tkat/Rapgef6tm1.1Tkat
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Gnao1tm2.1Rneu/Gnao1+
Genetic Background: B6.129S-Gnao1tm2.1Rneu

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gnao1tm1Ejne/Gnao1tm1Ejne
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Zap70mur/Zap70mur
Genetic Background: C57BL/6Apb-Zap70mur/Apb

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
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Allelic Composition: Map2k1tm1Chrn/Map2k1tm1Chrn,Map2k2tm1Chrn/Map2k2tm1Chrn,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Gnao1tm1b(EUCOMM)Hmgu/Gnao1+
Genetic Background: C57BL/6N-Gnao1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex






 

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