Manteia

ENSGALG00000003163

Gallus gallus

Features

Gene ID:	ENSGALG00000003163

Biological name :	GNAO1

Synonyms :	GNAO1 / G protein subunit alpha o1

Possible biological names infered from orthology :	guanine nucleotide binding protein, alpha O / P09471 / P18872

Species:	Gallus gallus

Chr. number:	11
Strand:	1
Band:
Gene start:	2264902
Gene end:	2382477

Corresponding Affymetrix probe sets:	Gga.19063.1.S1_at (Chicken Array) GgaAffx.25767.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000004997 NCBI entrez gene - 415698 See in Manteia. RefSeq - NM_001277550 RefSeq Peptide - NP_001264479 swissprot - E1C347 Ensembl - ENSGALG00000003163

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gnao1a	ENSDARG00000016676	Danio rerio
gnao1b	ENSDARG00000036058	Danio rerio
GNAO1	ENSG00000087258	Homo sapiens
Gnao1	ENSMUSG00000031748	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
GNAI1 / guanine nucleotide-binding protein G(i) subunit alpha-1 / P63096* / B2RSH2* / G protein subunit alpha i1* / guanine nucleotide binding protein (G protein), alpha inhibiting 1*	ENSGALG00000008382	72
GNAI3 / guanine nucleotide-binding protein G(k) subunit alpha / P08754* / Q9DC51* / G protein subunit alpha i3* / guanine nucleotide binding protein (G protein), alpha inhibiting 3*	ENSGALG00000041700	72
GNAI2 / G protein subunit alpha i2 / P04899* / P08752* / guanine nucleotide binding protein (G protein), alpha inhibiting 2*	ENSGALG00000035645	71
GNAT2 / G protein subunit alpha transducin 2 / P19087* / P50149* / guanine nucleotide binding protein, alpha transducing 2*	ENSGALG00000038084	62
GNAZ / G protein subunit alpha z / O70443* / P19086* / guanine nucleotide binding protein, alpha z subunit*	ENSGALG00000006719	62
GNAT1 / G protein subunit alpha transducin 1 / P11488* / P20612* / guanine nucleotide binding protein, alpha transducing 1*	ENSGALG00000028697	62
GNAT3 / G protein subunit alpha transducin 3 / A8MTJ3* / Q3V3I2* / guanine nucleotide binding protein, alpha transducing 3*	ENSGALG00000008427	61
GNA14 / G protein subunit alpha 14 / O95837* / P30677* / guanine nucleotide binding protein, alpha 14*	ENSGALG00000015176	50
GNAQ / G protein subunit alpha q / P21279* / P50148* / guanine nucleotide binding protein, alpha q polypeptide*	ENSGALG00000015177	50
GNA11	ENSGALG00000003238	49
GNA13 / G protein subunit alpha 13 / P27601* / Q14344* / guanine nucleotide binding protein, alpha 13*	ENSGALG00000036028	42
GNA12 / G protein subunit alpha 12 / P27600* / Q03113* / guanine nucleotide binding protein, alpha 12*	ENSGALG00000004368	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408	G-protein alpha subunit, group I
IPR011025	G protein alpha subunit, helical insertion
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0007212	dopamine receptor signaling pathway	IEA
biological_process	GO:0007626	locomotory behavior	IEA
biological_process	GO:0008016	regulation of heart contraction	IEA
biological_process	GO:0009987	cellular process	IEA
cellular_component	GO:0005834	heterotrimeric G-protein complex	IBA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0043209	myelin sheath	IEA
cellular_component	GO:0044297	cell body	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0003924	GTPase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	IBA
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0019001	guanyl nucleotide binding	IEA
molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA
molecular_function	GO:0031821	G-protein coupled serotonin receptor binding	IBA
molecular_function	GO:0031852	mu-type opioid receptor binding	IBA
molecular_function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	IBA

Pathways (from Reactome)

Pathway description

PLC beta mediated events

G-protein activation

Ca2+ pathway

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000001334	GNB1 / G protein subunit beta 1 / P62873* / P62874* / guanine nucleotide binding protein (G protein), beta 1*	/ complex
ENSGALG00000027629	GNG2 / G protein subunit gamma 2 / P59768* / P63213* / guanine nucleotide binding protein (G protein), gamma 2*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr