Manteia - Molecule gene

ENSMUSG00000028777

Mus musculus

Features

Gene ID:	ENSMUSG00000028777

Biological name :	Gnat3

Synonyms :	Gnat3 / guanine nucleotide binding protein, alpha transducing 3 / Q3V3I2

Possible biological names infered from orthology :	A8MTJ3 / G protein subunit alpha transducin 3

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	A3
Gene start:	17962549
Gene end:	18019834

Corresponding Affymetrix probe sets:	10519905 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000030561 NCBI entrez gene - 242851 See in Manteia. MGI - MGI:3588268 RefSeq - NM_001081143 RefSeq Peptide - NP_001074612 swissprot - B2RVZ3 swissprot - Q3V3I2 Ensembl - ENSMUSG00000028777

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GNAT3	ENSGALG00000008427	Gallus gallus
GNAT3	ENSG00000214415	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*	ENSMUSG00000009108	80
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*	ENSMUSG00000034837	79
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*	ENSMUSG00000057614	67
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*	ENSMUSG00000032562	66
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*	ENSMUSG00000000001	65
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*	ENSMUSG00000031748	60
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*	ENSMUSG00000040009	58
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*	ENSMUSG00000034781	50
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*	ENSMUSG00000024639	50
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*	ENSMUSG00000024697	49
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*	ENSMUSG00000034792	42
Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*	ENSMUSG00000000149	41
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*	ENSMUSG00000020611	39

Protein motifs (from Interpro)

Interpro ID	Name
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408	G-protein alpha subunit, group I
IPR011025	G protein alpha subunit, helical insertion
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IDA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0035094	response to nicotine	IEA
biological_process	GO:0050909	sensory perception of taste	IMP
biological_process	GO:0050913	sensory perception of bitter taste	IMP
biological_process	GO:0050916	sensory perception of sweet taste	IMP
biological_process	GO:0050917	sensory perception of umami taste	IMP
cellular_component	GO:0001669	acrosomal vesicle	IEA
cellular_component	GO:0001750	photoreceptor outer segment	IBA
cellular_component	GO:0001917	photoreceptor inner segment	IBA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005930	axoneme	IEA
cellular_component	GO:0016324	apical plasma membrane	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IBA
molecular_function	GO:0003924	GTPase activity	IDA
molecular_function	GO:0004871	obsolete signal transducer activity	IBA
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0019001	guanyl nucleotide binding	IEA
molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

PLC beta mediated events

Adenylate cyclase inhibitory pathway

G-protein activation

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

ADP signalling through P2Y purinoceptor 12

G alpha (i) signalling events

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001986	taste sensitivity/ preferences		Show Allelic Composition: Gnao1^tm1Ejne/Gnao1^tm1Ejne Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004209	abnormal sweet taste sensitivity	"changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnao1^tm1Ejne/Gnao1^tm1Ejne Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004210	abnormal bitter taste sensitivity	"changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnao1^tm1Ejne/Gnao1^tm1Ejne Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004213	abnormal unami taste sensitivity	"changes in the ability to perceive a particular flavor or suggestion of something unami (savory) by the chemoreceptors of the gustatory system" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnao1^tm1Ejne/Gnao1^tm1Ejne Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Gnat1^tm1Clma/Gnat1^tm1Clma,Gnat3^tm1Rfm/Gnat3^tm1Rfm Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0005423	abnormal somatic nervous system physiology	"anomalous function of any of the cranial and spinal nerves or their ganglia or the peripheral sensory receptors" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Brca1^tm1Cxd/Brca1^tm1Cxd,Trp53^tm1Brd/Trp53^tm1Brd Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000024524	Gnal / Q8CGK7 / guanine nucleotide binding protein, alpha stimulating, olfactory type / P38405* / G protein subunit alpha L*	/ complex / reaction
ENSMUSG00000043004	Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*	/ complex / reaction
ENSMUSG00000023439	Gnb3 / Q61011 / guanine nucleotide binding protein (G protein), beta 3 / P16520* / G protein subunit beta 3*	/ complex
ENSMUSG00000029064	Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*	/ complex / reaction
ENSMUSG00000036353	P2ry12 / Q9CPV9 / purinergic receptor P2Y, G-protein coupled 12 / Q9H244* / purinergic receptor P2Y12*	/ reaction / complex
ENSMUSG00000025739	Gng13 / Q9JMF3 / guanine nucleotide binding protein (G protein), gamma 13 / Q9P2W3* / G protein subunit gamma 13*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr