ENSG00000214415


Homo sapiens

Features
Gene ID: ENSG00000214415
  
Biological name :GNAT3
  
Synonyms : A8MTJ3 / GNAT3 / G protein subunit alpha transducin 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.11
Gene start: 80458671
Gene end: 80512020
  
Corresponding Affymetrix probe sets: 216590_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000381339
NCBI entrez gene - 346562     See in Manteia.
OMIM - 139395
RefSeq - NM_001102386
RefSeq - XM_011516124
RefSeq Peptide - NP_001095856
swissprot - A8MTJ3
Ensembl - ENSG00000214415
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAT3ENSGALG00000008427Gallus gallus
 Gnat3ENSMUSG00000028777Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418380
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434978
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435369
GNAI1 / P63096 / G protein subunit alpha i1ENSG0000012795568
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513568
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725861
GNAZ / P19086 / G protein subunit alpha zENSG0000012826658
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825650
GNAQ / P50148 / G protein subunit alpha qENSG0000015605249
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604949
GNA15 / P30679 / G protein subunit alpha 15ENSG0000006055843
GNA12 / Q03113 / G protein subunit alpha 12ENSG0000014653541
GNA13 / Q14344 / G protein subunit alpha 13ENSG0000012006338


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0050909 sensory perception of taste IEA
 biological_processGO:0050913 sensory perception of bitter taste IEA
 biological_processGO:0050916 sensory perception of sweet taste IEA
 biological_processGO:0050917 sensory perception of umami taste IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0001750 photoreceptor outer segment IBA
 cellular_componentGO:0001917 photoreceptor inner segment IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005525 GTP binding TAS
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
Adenylate cyclase inhibitory pathway
G-protein activation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
ADP signalling through P2Y purinoceptor 12
G alpha (s) signalling events
G alpha (i) signalling events
G alpha (z) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141404 GNAL / P38405 / G protein subunit alpha L  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / reaction / complex
 ENSG00000169313 P2RY12 / Q9H244 / purinergic receptor P2Y12  / complex / reaction
 ENSG00000127588 GNG13 / Q9P2W3 / G protein subunit gamma 13  / complex
 ENSG00000111664 GNB3 / P16520 / G protein subunit beta 3  / complex






 

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