ENSG00000146535


Homo sapiens

Features
Gene ID: ENSG00000146535
  
Biological name :GNA12
  
Synonyms : GNA12 / G protein subunit alpha 12 / Q03113
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.2
Gene start: 2728112
Gene end: 2844324
  
Corresponding Affymetrix probe sets: 221737_at (Human Genome U133 Plus 2.0 Array)   224681_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386054
Ensembl peptide - ENSP00000391462
Ensembl peptide - ENSP00000275364
Ensembl peptide - ENSP00000385935
NCBI entrez gene - 2768     See in Manteia.
OMIM - 604394
RefSeq - XM_017012008
RefSeq - NM_001282440
RefSeq - NM_001282441
RefSeq - NM_001293092
RefSeq - NM_007353
RefSeq Peptide - NP_001280021
RefSeq Peptide - NP_031379
RefSeq Peptide - NP_001269370
RefSeq Peptide - NP_001269369
swissprot - E9PC54
swissprot - C9J2Y7
swissprot - Q03113
Ensembl - ENSG00000146535
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gna12aENSDARG00000025826Danio rerio
 GNA12ENSGALG00000004368Gallus gallus
 Gna12ENSMUSG00000000149Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GNA13 / Q14344 / G protein subunit alpha 13ENSG0000012006363
GNAQ / P50148 / G protein subunit alpha qENSG0000015605240
GNA11 / P29992 / G protein subunit alpha 11ENSG0000008825639
GNAI1 / P63096 / G protein subunit alpha i1ENSG0000012795538
GNAZ / P19086 / G protein subunit alpha zENSG0000012826638
GNAO1 / P09471 / G protein subunit alpha o1ENSG0000008725838
GNAI3 / P08754 / G protein subunit alpha i3ENSG0000006513538
GNA14 / O95837 / G protein subunit alpha 14ENSG0000015604938
GNAT3 / A8MTJ3 / G protein subunit alpha transducin 3ENSG0000021441538
GNAT2 / P19087 / G protein subunit alpha transducin 2ENSG0000013418337
GNAT1 / P11488 / G protein subunit alpha transducin 1ENSG0000011434937
GNAI2 / P04899 / G protein subunit alpha i2ENSG0000011435337
GNA15 / P30679 / G protein subunit alpha 15ENSG0000006055836


Protein motifs (from Interpro)
Interpro ID Name
 IPR000469  G-protein alpha subunit, group 12/13
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010762 regulation of fibroblast migration ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0032006 regulation of TOR signaling IMP
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0031752 D5 dopamine receptor binding IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (12/13) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127533 F2RL3 / Q96RI0 / F2R like thrombin or trypsin receptor 3  / reaction / complex
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction / complex
 ENSG00000164220 F2RL2 / O00254 / coagulation factor II thrombin receptor like 2  / complex / reaction
 ENSG00000170214 ADRA1B / P35368 / adrenoceptor alpha 1B  / complex / reaction
 ENSG00000181104 F2R / P25116 / coagulation factor II thrombin receptor  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000171873 ADRA1D / P25100 / adrenoceptor alpha 1D  / reaction / complex
 ENSG00000006638 P21731 / TBXA2R / thromboxane A2 receptor  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000120907 ADRA1A / P35348 / adrenoceptor alpha 1A  / complex / reaction
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / complex / reaction






 

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