ENSG00000006638


Homo sapiens

Features
Gene ID: ENSG00000006638
  
Biological name :TBXA2R
  
Synonyms : P21731 / TBXA2R / thromboxane A2 receptor
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3594506
Gene end: 3606840
  
Corresponding Affymetrix probe sets: 207554_x_at (Human Genome U133 Plus 2.0 Array)   207555_s_at (Human Genome U133 Plus 2.0 Array)   211590_x_at (Human Genome U133 Plus 2.0 Array)   336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364336
Ensembl peptide - ENSP00000393333
Ensembl peptide - ENSP00000468145
NCBI entrez gene - 6915     See in Manteia.
OMIM - 188070
RefSeq - XM_011528214
RefSeq - NM_001060
RefSeq - NM_201636
RefSeq Peptide - NP_001051
RefSeq Peptide - NP_963998
swissprot - P21731
swissprot - K7ER80
Ensembl - ENSG00000006638
  
Related genetic diseases (OMIM): 614009 - {Bleeding disorder, platelet-type, 13, susceptibility to}, 614009
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbxa2rENSDARG00000104717Danio rerio
 TBXA2RENSGALG00000037888Gallus gallus
 P30987ENSMUSG00000034881Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P34995 / PTGER1 / prostaglandin E receptor 1ENSG0000016095131
PTGFR / P43088 / prostaglandin F receptorENSG0000012242030
P43115 / PTGER3 / prostaglandin E receptor 3ENSG0000005062828
PTGIR / P43119 / prostaglandin I2 receptorENSG0000016001324
PTGDR / Q13258 / prostaglandin D2 receptorENSG0000016822922
P43116 / PTGER2 / prostaglandin E receptor 2ENSG0000012538421
P35408 / PTGER4 / prostaglandin E receptor 4ENSG0000017152220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001105  Thromboxane receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019932 second-messenger-mediated signaling IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0038193 thromboxane A2 signaling pathway IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IGI
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004960 thromboxane receptor activity IEA
 molecular_functionGO:0004961 thromboxane A2 receptor activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / complex / reaction
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / complex / reaction
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / reaction / complex
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / reaction / complex
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / reaction / complex
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction






 

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