ENSMUSG00000034881


Mus musculus

Features
Gene ID: ENSMUSG00000034881
  
Biological name :Tbxa2r
  
Synonyms : P30987 / Tbxa2r / thromboxane A2 receptor
  
Possible biological names infered from orthology : P21731
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81328731
Gene end: 81335172
  
Corresponding Affymetrix probe sets: 10365098 (MoGene1.0st)   1419222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100962
Ensembl peptide - ENSMUSP00000151447
NCBI entrez gene - 21390     See in Manteia.
MGI - MGI:98496
RefSeq - XM_006513460
RefSeq - NM_001277265
RefSeq - NM_009325
RefSeq Peptide - NP_001345441
RefSeq Peptide - NP_033351
RefSeq Peptide - NP_001264194
swissprot - P30987
swissprot - Q5FW61
Ensembl - ENSMUSG00000034881
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbxa2rENSDARG00000104717Danio rerio
 TBXA2RENSGALG00000037888Gallus gallus
 P21731ENSG00000006638Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803635
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*ENSMUSG0000001946434
Ptger3 / prostaglandin E receptor 3 / P43115*ENSMUSG0000004001631
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*ENSMUSG0000004301727
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*ENSMUSG0000007148924
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994224
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*ENSMUSG0000003775923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001105  Thromboxane receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0019229 regulation of vasoconstriction IGI
 biological_processGO:0019932 second-messenger-mediated signaling IDA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0038193 thromboxane A2 signaling pathway IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0090051 negative regulation of cell migration involved in sprouting angiogenesis IEA
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004960 thromboxane receptor activity IDA
 molecular_functionGO:0004961 thromboxane A2 receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002328 abnormal airway resistance "anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpctm1Brd/Xpctm1Brd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1.1Bhk,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Tbxa2rtm1Cof/Tbxa2rtm1Cof
Genetic Background: involves: 129P2/OlaHsd

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gab1tm1Ajw/Gab1tm1Ajw
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009548 abnormal platelet aggregation "any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009818 abnormal thromboxane level 
Show

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000149 Gna12 / P27600 / guanine nucleotide binding protein, alpha 12 / Q03113* / G protein subunit alpha 12*  / reaction / complex
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / complex / reaction
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / complex / reaction
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / reaction / complex
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / complex / reaction
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex






 

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