Manteia - Molecule gene

ENSMUSG00000039942

Mus musculus

Features

Gene ID:	ENSMUSG00000039942

Biological name :	Ptger4

Synonyms :	P32240 / prostaglandin E receptor 4 (subtype EP4) / Ptger4

Possible biological names infered from orthology :	P35408 / prostaglandin E receptor 4

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	A1
Gene start:	5206661
Gene end:	5244187

Corresponding Affymetrix probe sets:	10427461 (MoGene1.0st) 1421073_a_at (Mouse Genome 430 2.0 Array) 1424208_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048736 Ensembl peptide - ENSMUSP00000112858 NCBI entrez gene - 19219 See in Manteia. MGI - MGI:104311 RefSeq - NM_008965 RefSeq - NM_001136079 RefSeq Peptide - NP_001129551 RefSeq Peptide - NP_032991 swissprot - P32240 swissprot - Q91VE4 Ensembl - ENSMUSG00000039942

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ptger4a	ENSDARG00000059236	Danio rerio
ptger4b	ENSDARG00000035415	Danio rerio
PTGER4	ENSGALG00000014824	Gallus gallus
P35408	ENSG00000171522	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*	ENSMUSG00000043017	23
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*	ENSMUSG00000037759	22
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*	ENSMUSG00000071489	21
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*	ENSMUSG00000019464	19
Ptger3 / prostaglandin E receptor 3 / P43115*	ENSMUSG00000040016	19
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*	ENSMUSG00000034881	16
Ptgfr / P43117 / prostaglandin F receptor / P43088*	ENSMUSG00000028036	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR001244	Prostaglandin DP receptor
IPR001758	Prostanoid EP4 receptor
IPR008365	Prostanoid receptor
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	TAS
biological_process	GO:0007254	JNK cascade	ISS
biological_process	GO:0009612	response to mechanical stimulus	IEA
biological_process	GO:0030278	regulation of ossification	IMP
biological_process	GO:0032496	response to lipopolysaccharide	IMP
biological_process	GO:0033624	negative regulation of integrin activation	IEA
biological_process	GO:0042093	T-helper cell differentiation	IDA
biological_process	GO:0050710	negative regulation of cytokine secretion	IMP
biological_process	GO:0050715	positive regulation of cytokine secretion	IDA
biological_process	GO:0050728	negative regulation of inflammatory response	IEA
biological_process	GO:0050729	positive regulation of inflammatory response	IDA
biological_process	GO:0051492	regulation of stress fiber assembly	IDA
biological_process	GO:0060348	bone development	ISS
biological_process	GO:0070371	ERK1 and ERK2 cascade	ISS
biological_process	GO:0071260	cellular response to mechanical stimulus	IEP
biological_process	GO:0071380	cellular response to prostaglandin E stimulus	IBA
biological_process	GO:2000420	negative regulation of eosinophil extravasation	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004955	prostaglandin receptor activity	IEA
molecular_function	GO:0004957	prostaglandin E receptor activity	TAS

Pathways (from Reactome)

Pathway description

Prostanoid ligand receptors

G alpha (s) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Dusp5^{tm1d(KOMP)Wtsi}/Dusp5^{tm1d(KOMP)Wtsi} Genetic Background: B6(Cg)-Dusp5^{tm1d(KOMP)Wtsi}
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Dusp5^{tm1d(KOMP)Wtsi}/Dusp5^{tm1d(KOMP)Wtsi} Genetic Background: B6(Cg)-Dusp5^{tm1d(KOMP)Wtsi}
MP:0000364	abnormal vascular regression	"premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001182	lung hemorrhage	"bleeding in the respiratory organs" [J:66345]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0001828	abnormal T cell activation	"anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001853	heart inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dusp5^{tm1d(KOMP)Wtsi}/Dusp5^{tm1d(KOMP)Wtsi} Genetic Background: B6(Cg)-Dusp5^{tm1d(KOMP)Wtsi}
MP:0002009	preneoplasia	"state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm2Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J
MP:0002058	neonatal lethality	"death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pafah1b1^tm1Awb/Pafah1b1⁺ Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss
MP:0002081	perinatal lethality	"death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: S100a10^tm1Jnw/S100a10^tm1Jnw,Scn10a^tm2(cre)Jnw/Scn10a⁺ Genetic Background: involves: 129 * C57BL/6
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptger4^tm1Matb/Ptger4^tm1Matb Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002295	abnormal pulmonary circulation	"anomalous circulation of blood through the lungs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0003035	decreased pulmonary vascular resistance	"less than the normal force opposing blood flow in the lung blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003139	patent ductus arteriosus	"failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv Allelic Composition: Ptger4^tm1Matb/Ptger4^tm1Matb Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ptger4^tm1.2Matb/Ptger4^tm1.2Matb Genetic Background: involves: 129S6/SvEvTac * C57BL/6
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0003561	rheumatoid arthritis	"an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0003658	abnormal capillaries	"malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003828	pulmonary edema	"an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0004038	lymphangiectasis	"dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0004231	abnormal calcium ion homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Prrx1^tm1Tex/Prrx1^tm1Tex,Prrx2^tm1Mjk/Prrx2^tm1Mjk Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ptger4^tm1.2Matb/Ptger4⁺ Genetic Background: B6.129S6-Ptger4^tm1.2Matb
MP:0004502	decreased incidence of chemically-induced tumors	"lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itgb2^tm1Bay/Itgb2^tm2Bay Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005202	lethargy	"mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005362	abnormal Langerhans cell physiology	"atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	"less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008595	abnormal circulating interleukin-6 level	"anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0008713	abnormal cytokine level	"deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009811	abnormal prostaglandin level	"anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0010018	lung vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0010019	liver vascular congestion	"obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0010214	abnormal circulating serum amyloid protein level	"deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis" [MESH:D12.776.049.790, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: involves: 101/H * C3H/HeH * STOCK MR
MP:0010557	dilated pulmonary artery	"the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psen1^tm1Shn/Psen1^tm1Shn Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010630	abnormal cardiac muscle tissue morphology	"any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N
MP:0010909	pulmonary alveolar hemorrhage	"bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ptger4^tm1Bhk/Ptger4^tm1Bhk Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Ptger4^tm1.1Matb/Ptger4^tm1.1Matb,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr