ENSMUSG00000071489


Mus musculus

Features
Gene ID: ENSMUSG00000071489
  
Biological name :Ptgdr
  
Synonyms : P70263 / Prostaglandin D2 receptor / Ptgdr
  
Possible biological names infered from orthology : Q13258
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C1
Gene start: 44851235
Gene end: 44859375
  
Corresponding Affymetrix probe sets: 10419167 (MoGene1.0st)   1422171_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093653
NCBI entrez gene - 19214     See in Manteia.
MGI - MGI:102966
RefSeq - NM_008962
RefSeq Peptide - NP_032988
swissprot - P70263
Ensembl - ENSMUSG00000071489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTGDRENSGALG00000029768Gallus gallus
 PTGDRENSG00000168229Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*ENSMUSG0000003775940
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*ENSMUSG0000004301740
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994231
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*ENSMUSG0000001946424
Ptger3 / prostaglandin E receptor 3 / P43115*ENSMUSG0000004001624
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*ENSMUSG0000003488123
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000376  Prostaglandin D receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030238 male sex determination IMP
 biological_processGO:0030431 sleep IMP
 biological_processGO:0046085 adenosine metabolic process IMP
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IBA
 biological_processGO:0071799 cellular response to prostaglandin D stimulus IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IBA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001785 prostaglandin J receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004956 prostaglandin D receptor activity IDA
 molecular_functionGO:0004957 prostaglandin E receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000362 reduced histamine storage "decreased amounts of this potent vasoactive peptide stored in mast cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ptgdrtm1Dgen/Ptgdr+
Genetic Background: B6.129P2-Ptgdrtm1Dgen

 MP:0001619 abnormal vascular permeability "anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Hpgdstm1Urad/Hpgdstm1Urad
Genetic Background: B6.Cg-Hpgdstm1Urad Galctwi

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Galctwi/Galctwi,Ptgdrtm1Sna/Ptgdrtm1Sna
Genetic Background: B6.Cg-Galctwi Ptgdrtm1Sna

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Neurod1tm1Jle/Neurod1tm1Jle
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
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Allelic Composition: Ptchd1tm1b(KOMP)IcsOrl/Ptchd1tm1b(KOMP)IcsOrl
Genetic Background: C57BL/6N-Ptchd1tm1b(KOMP)IcsOrl/Ics

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptchd1tm1b(KOMP)IcsOrl/Ptchd1tm1b(KOMP)IcsOrl
Genetic Background: C57BL/6N-Ptchd1tm1b(KOMP)IcsOrl/Ics

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ptgdrtm1Dgen/Ptgdrtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ptgdrtm1Dgen/Ptgdrtm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptgdrtm1Dgen/Ptgdr+
Genetic Background: B6.129P2-Ptgdrtm1Dgen

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdf7tm3(cre)Tmj/Gdf7+,Otx2tm6Asim/Otx2tm6Asim,Tg(CAG-cat,-EGFP)1Rbns/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ptgdrtm1Dgen/Ptgdr+
Genetic Background: B6.129P2-Ptgdrtm1Dgen

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0008020 abnormal dermal mast cell morphology "any structural anomaly in cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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