ENSMUSG00000019464


Mus musculus

Features
Gene ID: ENSMUSG00000019464
  
Biological name :Ptger1
  
Synonyms : P35375 / Prostaglandin E2 receptor EP1 subtype / Ptger1
  
Possible biological names infered from orthology : P34995 / prostaglandin E receptor 1
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 83666678
Gene end: 83672753
  
Corresponding Affymetrix probe sets: 10573210 (MoGene1.0st)   1445445_s_at (Mouse Genome 430 2.0 Array)   1450491_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019608
NCBI entrez gene - 19216     See in Manteia.
MGI - MGI:97793
RefSeq - XM_006530771
RefSeq - NM_013641
RefSeq Peptide - NP_038669
swissprot - P35375
swissprot - B2RS62
Ensembl - ENSMUSG00000019464
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptger1aENSDARG00000078605Danio rerio
 ptger1bENSDARG00000104847Danio rerio
 P34995ENSG00000160951Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803631
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*ENSMUSG0000003488129
Ptger3 / prostaglandin E receptor 3 / P43115*ENSMUSG0000004001628
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994224
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*ENSMUSG0000007148921
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*ENSMUSG0000003775921
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*ENSMUSG0000004301721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000708  Prostanoid EP1 receptor
 IPR001244  Prostaglandin DP receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004955 prostaglandin receptor activity IEA
 molecular_functionGO:0004957 prostaglandin E receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001354 increased aggression towards males "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cfmq3129X1/SvJ/Cfmq3C57BL/6J,Cftrtm1Unc/Cftrtm1Unc
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002351 abnormal cervical lymph node morphology "anomalous structure, development, or number of the lymph nodes found near the neck and shoulders" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Foxp3tm2Flv/Y
Genetic Background: involves: C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt9btm1Amc/Wnt9btm1Amc
Genetic Background: involves: 129X1/SvJ

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptger1tm1Sna/Ptger1tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6Cr

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Terttm1Sear/Terttm1Sear
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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