ENSMUSG00000037759


Mus musculus

Features
Gene ID: ENSMUSG00000037759
  
Biological name :Ptger2
  
Synonyms : prostaglandin E receptor 2 (subtype EP2) / Ptger2 / Q62053
  
Possible biological names infered from orthology : P43116 / prostaglandin E receptor 2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 44988195
Gene end: 45003820
  
Corresponding Affymetrix probe sets: 10414271 (MoGene1.0st)   1449310_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038483
NCBI entrez gene - 19217     See in Manteia.
MGI - MGI:97794
RefSeq - NM_008964
RefSeq Peptide - NP_032990
swissprot - Q543A9
swissprot - Q62053
Ensembl - ENSMUSG00000037759
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptger2aENSDARG00000011434Danio rerio
 ptger2bENSDARG00000037033Danio rerio
 PTGER2ENSGALG00000012396Gallus gallus
 P43116ENSG00000125384Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*ENSMUSG0000007148940
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*ENSMUSG0000004301740
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994231
Ptger3 / prostaglandin E receptor 3 / P43115*ENSMUSG0000004001626
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*ENSMUSG0000001946424
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*ENSMUSG0000003488121
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001923  Prostanoid EP2 receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032570 response to progesterone IDA
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004957 prostaglandin E receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prdm1tm1Masu/Prdm1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0001562 abnormal circulating calcium level "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Liftm1Stw/Liftm1Stw
Genetic Background: involves: 129S/SvEv * 129S1/Sv

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ptger2tm1.1Kand/Ptger2tm1.1Kand,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0004504 decreased incidence of UV-induced tumors "lower than normal frequency of tumor incidence induced by exposure to ultraviolet light" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac * BALB/c

Allelic Composition: Hrhr/Hrhr,Ptger2tm1Brey/Ptger2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SKH1

 MP:0005581 abnormal renin activity "alterated ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptger2tm2Bhk/Ptger2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger2tm1Brey/Ptger2tm1Brey
Genetic Background: involves: 129S6/SvEvTac

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax1Un-s/Pax1Un-s
Genetic Background: B6.CC57BR-Pax1Un-s

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger2tm1.1Kand/Ptger2tm1.1Kand,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptger2tm1.1Kand/Ptger2tm1.1Kand,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptger2tm1.1Kand/Ptger2tm1.1Kand,Tg(ITGAM-cre)2781Gkl/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009373 abnormal cumulus expansion "defective or reduced ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009374 failure of cumulus expansion "complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger2tm1Sna/Ptger2tm1Sna
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009648 abnormal superovulation "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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