ENSMUSG00000040016


Mus musculus

Features
Gene ID: ENSMUSG00000040016
  
Biological name :Ptger3
  
Synonyms : prostaglandin E receptor 3 / Ptger3
  
Possible biological names infered from orthology : P43115
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H4
Gene start: 157566892
Gene end: 157645888
  
Corresponding Affymetrix probe sets: 10497079 (MoGene1.0st)   1425251_at (Mouse Genome 430 2.0 Array)   1440369_at (Mouse Genome 430 2.0 Array)   1450344_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043302
Ensembl peptide - ENSMUSP00000134137
NCBI entrez gene - 19218     See in Manteia.
MGI - MGI:97795
RefSeq - XM_011240038
RefSeq - NM_011196
RefSeq - XM_006501140
RefSeq - XM_011240037
RefSeq Peptide - NP_035326
swissprot - G3UYL9
swissprot - Q6PDF2
Ensembl - ENSMUSG00000040016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptger3ENSDARG00000055781Danio rerio
 PTGER3ENSGALG00000023142Gallus gallus
 P43115ENSG00000050628Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*ENSMUSG0000001946432
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803631
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*ENSMUSG0000003488129
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994227
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*ENSMUSG0000003775926
Ptgir / P43252 / Prostacyclin receptor / P43119* / prostaglandin I2 receptor*ENSMUSG0000004301726
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*ENSMUSG0000007148924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000154  Prostanoid EP3 receptor type 3
 IPR000265  Prostanoid EP3 receptor
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001244  Prostaglandin DP receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004955 prostaglandin receptor activity IEA
 molecular_functionGO:0004957 prostaglandin E receptor activity IEA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N

 MP:0002664 decreased circulating adrenocorticotropin level "decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0002987 abnormal urine osmolarity "changes in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Alox5aptm1Jdm/Alox5ap+
Genetic Background: DBA/1LacJ-Alox5aptm1Jdm

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf11atm1.1Pngr/Tnfrsf11atm1.2Pngr,Tg(Gfap-cre)2Brn/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
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Allelic Composition: Psen1tm1Shn/Psen1tm1Shn
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: B6.129P2-Ptger3tm1Sna

Allelic Composition: Ptger3tm1Csml/Ptger3tm1Csml
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ptger3tm1Csml/Ptger3tm1Csml,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: involves: 129P2/OlaHsd

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0005525 increased renal plasma flow rate "greater than the normal volume of plasma passing throught the kidney per unit time" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0005530 decreased renal vascular resistance "less than the normal force opposing blood flow in the kidney blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb2tm1Bay/Itgb2tm2Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna
Genetic Background: B6.129P2-Ptger3tm1Sna

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Ptger3tm1Csml/Ptger3tm1Csml,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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