ENSMUSG00000043017


Mus musculus

Features
Gene ID: ENSMUSG00000043017
  
Biological name :Ptgir
  
Synonyms : P43252 / Prostacyclin receptor / Ptgir
  
Possible biological names infered from orthology : P43119 / prostaglandin I2 receptor
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A2
Gene start: 16906490
Gene end: 16910905
  
Corresponding Affymetrix probe sets: 10550394 (MoGene1.0st)   1427313_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122080
Ensembl peptide - ENSMUSP00000083270
NCBI entrez gene - 19222     See in Manteia.
MGI - MGI:99535
RefSeq - NM_008967
RefSeq - XM_006539670
RefSeq Peptide - NP_032993
swissprot - E9PY53
swissprot - P43252
Ensembl - ENSMUSG00000043017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgirENSDARG00000038278Danio rerio
 PTGIRENSG00000160013Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ptger2 / Q62053 / prostaglandin E receptor 2 (subtype EP2) / P43116* / prostaglandin E receptor 2*ENSMUSG0000003775934
Ptgdr / P70263 / Prostaglandin D2 receptor / Q13258*ENSMUSG0000007148934
P32240 / Ptger4 / prostaglandin E receptor 4 (subtype EP4) / P35408* / prostaglandin E receptor 4*ENSMUSG0000003994229
Ptger3 / prostaglandin E receptor 3 / P43115*ENSMUSG0000004001623
P30987 / Tbxa2r / thromboxane A2 receptor / P21731*ENSMUSG0000003488122
P35375 / Ptger1 / Prostaglandin E2 receptor EP1 subtype / P34995* / prostaglandin E receptor 1*ENSMUSG0000001946421
Ptgfr / P43117 / prostaglandin F receptor / P43088*ENSMUSG0000002803619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000370  Prostacyclin (prostanoid IP) receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IMP
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016501 prostacyclin receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005413 vascular restenosis "recurrent narrowing or constriction of a blood vessel following surgical or mechanical injury " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0009818 abnormal thromboxane level 
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ptger4tm1Bhk/Ptger4tm1Bhk
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / reaction / complex
 ENSMUSG00000027523 Gnas / Q9Z0F1 / P63094 / Q6R0H6 / Q6R0H7 / GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus / P84996* / Q5JWF2* / O95467* / P63092* / GNAS complex locus*  / reaction / complex






 

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