ENSG00000160013


Homo sapiens

Features
Gene ID: ENSG00000160013
  
Biological name :PTGIR
  
Synonyms : P43119 / prostaglandin I2 receptor / PTGIR
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.32
Gene start: 46620468
Gene end: 46625118
  
Corresponding Affymetrix probe sets: 1555620_a_at (Human Genome U133 Plus 2.0 Array)   206187_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000291294
Ensembl peptide - ENSP00000469408
Ensembl peptide - ENSP00000470566
Ensembl peptide - ENSP00000470799
Ensembl peptide - ENSP00000468970
NCBI entrez gene - 5739     See in Manteia.
OMIM - 600022
RefSeq - XM_005259095
RefSeq - NM_000960
RefSeq - XM_005259093
RefSeq Peptide - NP_000951
swissprot - M0QZW0
swissprot - A0A0B4J2A7
swissprot - P43119
swissprot - M0QXV5
swissprot - M0QZI2
Ensembl - ENSG00000160013
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptgirENSDARG00000038278Danio rerio
 PtgirENSMUSG00000043017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P43116 / PTGER2 / prostaglandin E receptor 2ENSG0000012538437
PTGDR / Q13258 / prostaglandin D2 receptorENSG0000016822935
P35408 / PTGER4 / prostaglandin E receptor 4ENSG0000017152233
P21731 / TBXA2R / thromboxane A2 receptorENSG0000000663825
P43115 / PTGER3 / prostaglandin E receptor 3ENSG0000005062825
P34995 / PTGER1 / prostaglandin E receptor 1ENSG0000016095123
PTGFR / P43088 / prostaglandin F receptorENSG0000012242021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000370  Prostacyclin (prostanoid IP) receptor
 IPR008365  Prostanoid receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0016501 prostacyclin receptor activity IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
Prostacyclin signalling through prostacyclin receptor
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186469 GNG2 / P59768 / G protein subunit gamma 2  / complex / reaction
 ENSG00000078369 GNB1 / P62873 / G protein subunit beta 1  / complex / reaction
 ENSG00000087460 GNAS / O95467 / Q5JWF2 / P63092 / P84996 / GNAS complex locus  / reaction / complex






 

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