ENSMUSG00000000149


Mus musculus

Features
Gene ID: ENSMUSG00000000149
  
Biological name :Gna12
  
Synonyms : Gna12 / guanine nucleotide binding protein, alpha 12 / P27600
  
Possible biological names infered from orthology : G protein subunit alpha 12 / Q03113
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 140758408
Gene end: 140830431
  
Corresponding Affymetrix probe sets: 10535273 (MoGene1.0st)   1421026_at (Mouse Genome 430 2.0 Array)   1439206_at (Mouse Genome 430 2.0 Array)   1450096_at (Mouse Genome 430 2.0 Array)   1450097_s_at (Mouse Genome 430 2.0 Array)   1455008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143414
Ensembl peptide - ENSMUSP00000000153
NCBI entrez gene - 14673     See in Manteia.
MGI - MGI:95767
RefSeq - NM_010302
RefSeq Peptide - NP_034432
swissprot - A0A0G2JG40
swissprot - P27600
Ensembl - ENSMUSG00000000149
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gna12aENSDARG00000025826Danio rerio
 GNA12ENSGALG00000004368Gallus gallus
 GNA12ENSG00000146535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*ENSMUSG0000002061164
Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*ENSMUSG0000002463940
Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*ENSMUSG0000003478140
Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*ENSMUSG0000002469739
Gnaz / O70443 / guanine nucleotide binding protein, alpha z subunit / P19086* / G protein subunit alpha z*ENSMUSG0000004000938
Gnao1 / P18872 / guanine nucleotide binding protein, alpha O / P09471* / G protein subunit alpha o1*ENSMUSG0000003174838
Gnai1 / B2RSH2 / guanine nucleotide binding protein (G protein), alpha inhibiting 1 / P63096* / G protein subunit alpha i1*ENSMUSG0000005761438
Gnat3 / Q3V3I2 / guanine nucleotide binding protein, alpha transducing 3 / A8MTJ3* / G protein subunit alpha transducin 3*ENSMUSG0000002877738
Gnat2 / P50149 / guanine nucleotide binding protein, alpha transducing 2 / P19087* / G protein subunit alpha transducin 2*ENSMUSG0000000910838
Gnai3 / Q9DC51 / guanine nucleotide binding protein (G protein), alpha inhibiting 3 / P08754* / G protein subunit alpha i3*ENSMUSG0000000000138
Gnat1 / P20612 / guanine nucleotide binding protein, alpha transducing 1 / P11488* / G protein subunit alpha transducin 1*ENSMUSG0000003483737
Gnai2 / P08752 / guanine nucleotide binding protein (G protein), alpha inhibiting 2 / P04899* / G protein subunit alpha i2*ENSMUSG0000003256237
Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*ENSMUSG0000003479236


Protein motifs (from Interpro)
Interpro ID Name
 IPR000469  G-protein alpha subunit, group 12/13
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0032006 regulation of TOR signaling IEA
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042733 embryonic digit morphogenesis IGI
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005834 heterotrimeric G-protein complex TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA
 molecular_functionGO:0031752 D5 dopamine receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (12/13) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1(cre)Cgh/Grhl3+,Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+,Rac1tm1Djk/Rac1tm1Djk
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

Allelic Composition: Gna12tm1Citb/Gna12+,Gna13tm1Soff/Gna13tm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gnaqtm1Soff/Gnaqtm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

Allelic Composition: Gna12tm1Citb/Gna12+,Gna13tm1Soff/Gna13+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tymptm1Akiy/Tymptm1Akiy,Upp1tm1Akiy/Upp1tm1Akiy
Genetic Background: involves: 129X1/SvJ

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gna11tm1Soff/Gna11tm1Soff,Gnaqtm2Soff/Gnaqtm2Soff,X/Tg(Myh11-cre/ERT2)1Soff
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008176 abnormal germinal center B cell morphology "any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Npc1m1N/Npc1m1N
Genetic Background: BALB/cNctr-Npc1m1N/J

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Pcp2-cre)2Mpin/0,Tsc2tm1.1Mjg/Tsc2tm1.1Mjg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2.1Soff/Gna13tm2.1Soff,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: C57BL/6

Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm1Soff/Gna13+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna12tm1Citb/Gna12+,Gna13tm1Soff/Gna13tm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gna12tm1Citb/Gna12+,Gna13tm1Soff/Gna13tm1Soff
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Gna12tm1Citb/Gna12tm1Citb,Gna13tm2Cgh/Gna13tm2Cgh,Grhl3tm1(cre)Cgh/Grhl3+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021675 F2rl2 / O08675 / Proteinase-activated receptor 3 / O00254* / coagulation factor II thrombin receptor like 2*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000029064 Gnb1 / P62874 / guanine nucleotide binding protein (G protein), beta 1 / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSMUSG00000034881 P30987 / Tbxa2r / thromboxane A2 receptor / P21731*  / reaction / complex
 ENSMUSG00000043004 Gng2 / P63213 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / G protein subunit gamma 2*  / complex / reaction
 ENSMUSG00000050541 Adra1b / adrenoceptor alpha 1B / P35368*  / complex / reaction
 ENSMUSG00000045875 Adra1a / P97718 / Alpha-1A adrenergic receptor / P35348* / adrenoceptor alpha 1A*  / complex / reaction
 ENSMUSG00000027335 Adra1d / adrenoceptor alpha 1D / P25100*  / reaction / complex
 ENSMUSG00000050147 F2rl3 / O88634 / Proteinase-activated receptor 4 / Q96RI0* / F2R like thrombin or trypsin receptor 3*  / complex / reaction
 ENSMUSG00000053646 Plxnb1 / Q8CJH3 / plexin B1 / O43157*  / complex / reaction
 ENSMUSG00000059495 Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*  / reaction / complex






 

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